METHOD FOR PREPARATION OF BIOCOMPATIBLE AND BIOFUNCTIONAL MATERIALS AND PRODUCT THEREOF

• US 3,826,678 A
• Filed: 06/06/1972
• Issued: 07/30/1974
• Est. Priority Date: 06/06/1972
• Status: Expired due to Term

• Current Assignee: Hoffman A, Schmer G
• Original Assignee: Hoffman A, Schmer G
• Inventors: HOFFMAN A, SCHMER G
• Application Number:
  US05/260,237
• Time in Patent Office: 784 Days
• US Class Current: 428/420
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 33/0005 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 33/0029 using an intermediate layer of polymer
• CPC Class Codes: A61L 33/0047 Enzymes, e.g. urokinase, streptokinase
• CPC Class Codes: C08B 37/0075 Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
• CPC Class Codes: C08J 2375/04 Polyurethanes
• CPC Class Codes: C08J 7/12 Chemical modification
• CPC Class Codes: C12N 11/087 Acrylic polymers
• CPC Class Codes: C12N 11/093 Polyurethanes
• CPC Class Codes: Y10S 623/92 Method or apparatus for preparing or treating prosthetic
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/31536 Including interfacial reaction product of adjacent layers

Abstract

A METHOD FOR THE PREPARATION OF BIOCOMPATIBLE AND BIOFUNCTIONAL SURFACES IS PROVIDED BIOCOMPATIBLE AND
ATI N GRAFTING A REACTABLE COMPOUND SELECTED FROM THE GROU CONSISTING OF POLYMERS AND COPOLYMERS ONTO AN INERT UP
POL MERIC SUBSTRATE AND THEREAFTER CHEMICALLY BONDING A BIOLOGICALLY ACTIBE MOLECULE TO THE REATABLE COMPOUND SPECIFIC EMBODMENTS INCLUDE CHEMICALLY BONDING OF HUMAN SERUM ALBUMIN HEPARIN, STREPTOKINASE, PROSTAGLANDIN E-1 AND MIXTURES THEREOF TO HYDROGELS OF VARYING COMPOSITIONS WITH OR WITHOUT "ARM" SUC AS E-AMINO CAPROIC MOLECULE OR CHEMICAL "ARM" SUCAN INTERMEDIATE SMALLER ACID OR 1,4 DIAMINO BUTANE, THE HYDROGELS HAING BEEN PREVIOUSLY RADIATION-GRAFTED TO TOUGH INERT POLYMERIC SUBSTRATE. A HIGHLY SYNERGISTIC EFFECT IS ACHIEVED FOR HYDROGELS CONTAINING HIGH WATER CONTENT E.G., ABOVE ABOUT 55% WHEN THE CHEMICALLY BONDING OF THE BIOLOGICALLY ACTIVE MOLECULE IS CARRIED OUT VIA AN INTERMEDIATE SMALLER MOLECULE OR CHEMICALL ARM. FOR THIN FILM SUBSTRATES HAVING RAIATION-GRAFTED THERETO HYDROGELS WITH -CO2 PENDANT FUNCTIONAL GROUPS WHICH ARE ACTIVATED WITH A CARBODIIMIDE SOLUTION A QUICK WASH OF THE THIN FILM WITH ICE WATER IS REQUIRED TO EFFECT SUBSEQUENT CHEMICAL BONDING OF THE BIOLOGICALLY ACTIVE MOLECULES TO THE ACTIVATED SURFACE. THE SAME TECHNIQUE IS ALSO REQUIRED WHERE A CHEMICAL ARM IS EMPLOYED WHICH HAS -CO2H PENDANT FUNCTIONAL GROUPS.

Claims