METHOD AND DEVICE OF ARTIFICIAL ENDOCRINE PANCREAS

• US 3,827,565 A
• Filed: 05/16/1973
• Issued: 08/06/1974
• Est. Priority Date: 12/29/1969
• Status: Expired due to Term

• Current Assignee: Kenneth N. Matsumura
• Original Assignee: Kenneth N. Matsumura
• Inventors: Matsumura, Kenneth N.
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/360,981
• Time in Patent Office: 447 Days
• Field of Search: 210/22,321
• US Class Current: 210/632
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61M 1/16 with membranes

Abstract

A method for treating and changing the constitution of blood or other body fluid as the pancreatic islet cells effects such change normally in the blood or other body fluid passing therethrough in a live animal, in cooperation with or substitution for the animal endocrine pancreas; and a device for carrying out such treatment. The method comprises positioning on one side of a semi-permeable membrane and in contact therewith body fluid to be treated and the positioning on the opposite side of the membrane and proximate therewith once dispersed live pancreatic islet cells. The device comprises means associated with the membrane for positioning body fluid in contact with one side of the membrane, conduit means for introducing such fluid to and withdrawing it from the membrane, and once dispersed live pancreatic islet cells disposed on the other side of the membrane out of direct contact with the fluid. Additionally, the device may have a second membrane for dialyzing the fluid.

Claims

2. Apparatus of claim 1 wherein said membrane is permeable to molecules smaller than said cells.

3. Apparatus of claim 1 wherein the said cells are disposed in a layer having a thickness of about one cell.

4. Apparatus of claim 1 wherein the said membrane is of membrane type filter material.

5. Apparatus of claim 1 wherein the said cells are disposed in a confluent-superconfluent monolayer.

6. Apparatus of claim 1, and a second semipermeable membrane having one side juxtaposed to said first named membrane and containing said cells therebetween;

and means positioning dialysate liquid onto the opposite side of said second membrane and out of direct contact with said cells and body fluid.

7. Apparatus of claim 6:

wherein the said first named membrane is permeable to molecules smaller than said cells; and

said second named membrane is permeable to molecules smaller than protein molecules.

8. Method of treating body fluid comprising:

positioning of said fluid to be treated into contact with one side of a semipermeable membrane; and

positioning of once dispersed live pancreatic islet cells proximate the opposite side of said membrane.

9. Method of claim 8 wherein the said membrane is permeable to molecules smaller than said cells.

10. Method of claim 8, and positioning of one side of a second semipermeable membrane in juxtaposition to said first membrane for containing said cells therebetween;

and positioning dialysate liquid on the opposite side of said second membrane and out of direct contact with said cells and body fluid.

11. Method of claim 10:

wherein the said first named membrane is permeable to molecules smaller than said cells; and

said second named membrane is permeable to molecules smaller than protein molecules.

12. Method of claim 8, and dialyzing said fluid across a second semipermeable membrane with a dialysis liquid.