1,8-NAPHTHYRIDINE COMPOUNDS

• US 3,843,663 A
• Filed: 04/11/1973
• Issued: 10/22/1974
• Est. Priority Date: 05/05/1972
• Status: Expired due to Term

• Current Assignee: Clarence Stanley Rooney, Haydn Windsor Richard Williams
• Original Assignee: Clarence Stanley Rooney, Haydn Windsor Richard Williams
• Inventors: Williams, Haydn Windsor Richard, Rooney, Clarence Stanley
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US05/350,285
• Time in Patent Office: 559 Days
• Field of Search: 260/296N,294.8C
• US Class Current: 546/122
• CPC Class Codes: C07D 471/04 Ortho-condensed systems

Abstract

There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate Beta diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.

Claims

1. A 1,8-NAPHTHYRIDINE HAVING THE STRUCTURE 1

2. A product as claimed in claim 1 wherein R5 and R7 are each trifluoromethyl.

3. A compound as claimed in claim 1 wherein R5 is lower alkyl and R7 is trifluoromethyl.

4. A compound as claimed in claim 1 wherein R5 is trifluoromethyl and R7 is lower alkyl.

5. A compound as claimed in claim 1 wherein R5 is methyl and R7 is trifluoromethyl.

6. A compound as claimed in claim 1 wherein R5 is trifluoromethyl and R7 is methyl.

7. A compound as claimed in claim 1 wherein R5 is lower alkyl and R7 is pentafluoroethyl.

8. A compound as claimed in claim 1 wherein R5 is 2-thienyl and R7 is trifluoromethyl.