3-SUBSTITUTED-2-PYRIDONES IN THE TREATMENT OF PAIN, FEVER OR INFLAMMATION
First Claim
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1. A METHOD OF TREATING A DIEASE EXHIBITING THE SYMPTOMS OF PAIN, FEVER OR INFLAMMATION IN A HUMAN OR ANIMAL WHICH COMPRISES THE ADMINISTRATION OF ABOUT 0.5 MG./KG. TO ABOUT 70 MG./KG. PER DAY IN DOSAGE UNIT FORM OF A COMPOUND OF THE FORMULA:
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Abstract
Novel 3-substituted-2-pyridone and 3-substituted-2-thiopyridone compounds are disclosed and the processes for preparing the same are described. These compounds exhibit anti-inflammatory properties and also possess an effective degree of anti-pyretic and analgesic activity.
19 Citations
8 Claims
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1. A METHOD OF TREATING A DIEASE EXHIBITING THE SYMPTOMS OF PAIN, FEVER OR INFLAMMATION IN A HUMAN OR ANIMAL WHICH COMPRISES THE ADMINISTRATION OF ABOUT 0.5 MG./KG. TO ABOUT 70 MG./KG. PER DAY IN DOSAGE UNIT FORM OF A COMPOUND OF THE FORMULA:
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2. The method of claim 1 wherein A is O.
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3. The method of claim 1 wherein X is -CH CH-.
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4. The method of claim 1 wherein A is O and X is -CH CH-.
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5. A method according to claim 1 where A is O;
- Ar is phenyl;
R is hydrogen, loweralkyl, halogen, hydroxy, loweralkoxy, haloloweralkyl, nitro, amino, loweralkylamino or lowerdialkylamino;
R'"'"''"'"' is hydrogen;
X is -CH CH-; and
R1 is hydrogen, loweralkyl, phenyl loweralkyl, phenyl, or lowerdialkylaminoloweralkyl.
- Ar is phenyl;
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6. A method according to claim 5 where R and R1 are each hydrogen, thus administering 3-styryl-2(1H)pyridone.
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7. A method according to claim 1 where A is O;
- Ar is phenyl;
R is halogen;
X is -CH CH-; and
R2 is hydrogen.
- Ar is phenyl;
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8. A method according to claim 5 where R is o-chloro, and R1 is hydrogen thus administering 3-(o-chlorostyryl)-2(1H)-pyridone.
Specification
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Current AssigneeBruce E. Witzel, Gordon L. Walford, Tsung-Ying Shen
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Original AssigneeBruce E. Witzel, Gordon L. Walford, Tsung-Ying Shen
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InventorsShen, Tsung-Ying, Walford, Gordon L., Witzel, Bruce E.
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Primary Examiner(s)Friedman, Stanley J.
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Application NumberUS05/172,319Time in Patent Office1,177 DaysField of Search200/297Z,296R 424/263US Class Current514/345CPC Class CodesC07D 213/64 attached in position 2 or 6C07D 213/69 Two or more oxygen atomsC07D 213/70 Sulfur atomsC07D 213/71 to which a second hetero at...C07D 213/82 in position 3C07D 213/89 with hetero atoms directly ...
