APPARATUS FOR CONTROLLED SELECTIVE SEPARATION OF UNDESIRABLE CONSTITUENTS FROM BLOOD TO ACHIEVE A THERAPEUTIC EFFECT

• US 3,848,580 A
• Filed: 12/10/1971
• Issued: 11/19/1974
• Est. Priority Date: 12/11/1970
• Status: Expired due to Term

• Current Assignee: Fritz Victor Hasselblad, Viktor Holger Hyden
• Original Assignee: Fritz Victor Hasselblad, Viktor Holger Hyden
• Inventors: Hyden, Viktor Holger, Hasselblad, Fritz Victor
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US05/206,812
• Time in Patent Office: 1,075 Days
• Field of Search: 128/2G,2E,2L,2P,2R,2.5D,2.5E,2.5F,2.5R,2.1E,2.1R,214B,214C 356/39-41 73/422TC,423R
• US Class Current: 600/310
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621
• CPC Class Codes: A61M 2202/0433 Free haemoglobin
• CPC Class Codes: G01N 21/85 Investigating moving fluids or granular solids
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

Apparatus for controlled selective separation of undesirable constituents from blood for therapeutic purposes including a device having a plurality of active surfaces for separating predetermined constituents of the blood, a measuring cell having a light source at one end and a light detector at the other end to determine concentration of substances in the blood after filtering, a pressure control device, a sampling device and an alarm system responsive to predetermined value levels of pressure and concentration.

Claims

1. Therapeutic apparatus for controlled selective separation of constituents of blood flowing from a donor comprising a passage adapted to have blood flow therethrough a device communicating with said passage including a plurality of active surface means positioned to be contacted by the said flowing blood for separating predetermined constituents of the blood, and detection means communicating with the passage and said device for measuring characteristics of the flowing blood and for emitting a signal in response to a predetermined value of each such measured characteristic whereby the occurrence of an abnormality in or completion of said selective separation can be detected.

2. The therapeutic apparatus as recited in claim 1 wherein said detection means includes conduit means forming a measuring cell and having filter mEans defining a boundary of said cell to separate blood plasma, a light source in said cell and a light detector in said cell responsive to light directed from said light source through the blood to provide an electrical signal corresponding to the concentration of free haemoglobin in the blood and output means for communicating, said electrical signal to an alarm means whereby the occurrence of an abnormality in or completion of said selective separation can be detected.

3. The therapeutic apparatus as recited in claim 2 wherein said conduit means includes a conduit arranged parallel to said cell, and said filter means includes a first filter disposed at an inlet for said cell from said conduit and a second filter disposed at an outlet from said cell to said conduit downstream from said first filter.

4. The therapeutic apparatus as recited in claim 3 wherein said conduit means includes a throttling obstruction in said conduit adjacent said second filter to cause blood flow from said inlet to said outlet through said measuring cell.

5. The therapeutic apparatus as recited in claim 2 wherein said conduit means includes a conduit for through flow of blood past said measuring cell, and said measuring cell includes an inlet communicating with said conduit through said filter means and an outlet for communicating with a pressure lower than the pressure of blood in said conduit.

6. The therapeutic apparatus as recited in claim 2 wherein said detection means includes alarm means responsive to an electrical signal from said light detector to provide an alarm when the concentration of the free haemoglobin is above a predetermined value.

7. The therapeutic apparatus as recited in claim 6 wherein said detection means includes pressure sensing means for supplying an electrical signal to said alarm means to provide an alarm when the pressure of blood in said conduit means drops below a predetermined value.

8. The therapeutic apparatus as recited in claim 7 wherein said detection means includes sampling apparatus including a conduit having a plurality of apertures therein and a plurality of sample cylinders sealably received in said apertures.

9. The therapeutic apparatus as recited in claim 1 wherein said detection means includes sampling apparatus including a conduit having a plurality of apertures therein and a plurality of sample cylinders sealably received in said apertures.

10. The therapeutic apparatus as recited in claim 1 wherein said detection means includes pressure sensing means for providing an alarm when the pressure of blood in said passage drops below a predetermined value.