SOFT GELATIN CAPSULE CONTAINING HIGH WATER CONTENT FILL

• US 3,851,051 A
• Filed: 07/17/1970
• Issued: 11/26/1974
• Est. Priority Date: 07/17/1970
• Status: Expired due to Term

• Current Assignee: Connor E, Kindt W, Miskel J
• Original Assignee: Connor E, Kindt W, Miskel J
• Inventors: CONNOR E, MISKEL J, KINDT W
• Application Number:
  US05/055,993
• Time in Patent Office: 1,593 Days
• US Class Current: 424/455
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/4825 Proteins, e.g. gelatin gelatin capsule shells with substantial amounts of other macromolecular substances A61K9/4816
• CPC Class Codes: A61K 9/4866 Organic macromolecular compounds
• CPC Class Codes: Y10S 206/828 Medicinal content

Abstract

1. A FILLED ONE PIECE SOFT LEAK-TIGHT GELATIN CAPSULE CONSISTING ESSENTIALLY OF A SHELL FORMED FROM A FORMULATION COMPRISING GELATIN, INITIALLY 16-40 PARTS BY WEIGHT OF WATER, BASED ON THE TOTAL WEIGHT OF SAID FORMULATION, AND PLASTICIZER, AND A SOLID FILL CONTAINED WITHIN SAID SHELL, SAID FILL CONSISTING ESSENTIALLY OF: A SET RIGID GEL SYSTEM OF GELATIN, CASEIN, COLLAGEN, ALBUMIN, SOYA PROTEIN, OR SOYA PEPTONE IN THE FROM OF A WATER-SOLUBLE MACROMOLECULAR GEL LATTICE MATRIX WHICH CONTAINS FROM AT LEAST 5% TO AS MUCH AS 20% BY WEIGHT OF WATER, AND AN ACTIVE MEDICINAL INGREDIENT IN AQUEOUS SOLTUION, SUSPENSION OR DISPERSION, THE RATIO OF SAID ACTIVE INGREDIENT TO SAID MATRIX BEING FROM 1:1 TO 7:1 BY WEIGHT, THE WATER IN SAID FILL BEING IN MOISTURE EQUILIBRIUM WITH THE WATER IN SAID SHELL AND HAVING SUBSTANTIALLY NO DETERIORATING EFFECT UPON SAID SHELL.

Claims

1. A FILLED ONE PIECE SOFT LEAK-TIGHT GELATIN CAPSULE CONSISTING ESSENTIALLY OF A SHELL FORMED FROM A FORMULATION COMPRISING GELATIN, INITIALLY 16-40 PARTS BY WEIGHT OF WATER, BASED ON THE TOTAL WEIGHT OF SAID FORMULATION, AND PLASTICIZER, AND A SOLID FILL CONTAINED WITHIN SAID SHELL, SAID FILL CONSISTING ESSENTIALLY OF:

A SET RIGID GEL SYSTEM OF GELATIN, CASEIN, COLLAGEN, ALBUMIN, SOYA PROTEIN, OR SOYA PEPTONE IN THE FROM OF A WATER-SOLUBLE MACROMOLECULAR GEL LATTICE MATRIX WHICH CONTAINS FROM AT LEAST 5% TO AS MUCH AS 20% BY WEIGHT OF WATER, AND AN ACTIVE MEDICINAL INGREDIENT IN AQUEOUS SOLTUION, SUSPENSION OR DISPERSION, THE RATIO OF SAID ACTIVE INGREDIENT TO SAID MATRIX BEING FROM 1;

1 TO 7;

1 BY WEIGHT, THE WATER IN SAID FILL BEING IN MOISTURE EQUILIBRIUM WITH THE WATER IN SAID SHELL AND HAVING SUBSTANTIALLY NO DETERIORATING EFFECT UPON SAID SHELL.