IONIC BLOCK ELASTOMERIC POLYMERS

• US 3,853,804 A
• Filed: 07/16/1973
• Issued: 12/10/1974
• Est. Priority Date: 08/14/1970
• Status: Expired due to Term

• Current Assignee: Alan Rembaum, Shiao-Ping S. Yen
• Original Assignee: Alan Rembaum, Shiao-Ping S. Yen
• Inventors: Yen, Shiao-Ping S., Rembaum, Alan
• Primary Examiner(s): Goldstein, Melvin
• Assistant Examiner(s): Woodberry, Edward
• Application Number:
  US05/368,475
• Time in Patent Office: 512 Days
• Field of Search: 260/77.5Q,77.5AS,9,858,859,32.6N 424/183 117/62.1,138.8E,47A
• US Class Current: 524/233
• CPC Class Codes: A61L 33/0023 using a quaternized group or a protonated amine group of the substrate
• CPC Class Codes: C08G 18/0814 containing ammonium groups or groups forming them
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/3275 containing two hydroxy groups
• CPC Class Codes: C08G 18/329 containing aromatic groups
• CPC Class Codes: C08L 2666/26 Natural polymers, natural resins or derivatives thereof according to C08L1/00 - C08L5/00, C08L89/00, C08L93/00, C08L97/00 or C08L99/00
• CPC Class Codes: C08L 75/00 Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A neutral elastomer is prepared by the urethane linking reaction of diisocyanates with tertiary amino diols. The neutral elastomer is quaternized and is then reacted with an anionic polymer such as heparin to form ionically bonded block elastomeric copolymers. The heparin copolymer has non-thrombogenic characteristics. It can be dissolved in solvents and ultized to form a non-clotting coat on the blood lines in kidney machines.

Claims

1. A POLYMERIC SOLUTION CONSISTING ESSENTIALLY OF A POLYMER OF THE FORMULA:

2. A polymer solution according to claim 1 in which n is 10 to 1,000, A is halo, Z and Y are different members selected from the group consisting of isocyanate, hydroxyl, carboxyl and amino;

and R3, R4 and R5 are selected from the group consisting of lower alkyl and hydrogen, and R and R2 are lower alkylene.

3. A polymer solution according to claim 2 in which Z and Y are selected from isocyanate and hydroxyl and ZY is urethane.

4. A polymer solution according to claim 1 in which the solvent is a mixture of dimethylformamide and diaminoheptane.

5. A polymer solution according to claim 2 in which R is ethylene, R2 is methylene and R3, R4 and R5 are methyl.

6. A method of forming a cationic elastomeric polymer comprising the steps of forming a reaction mixture selected from the group consisting of:

7. A method according to claim 6 in which said molecular weight is from 1,000 to 3,000.

8. A method according to claim 7 where R3 and R4 are lower alkyl, Z is isocyanate, Y is hydroxyl, ZY is urethane and R5A is selected from the group consisting of hydrohalic acids, lower alkyl sulfate or lower alkyl halide.

9. A method according to claim 8 in which said quaternization reaction is conduced in the presence at least a 100 percent stoichiometric excess of the R5A reagent in a common solvent for said intermediate polymer and said cationic polymer.

10. A method according to claim 6 in which said solvent is a mixture of dimethylformamide and diaminoheptane.