THIAXANTHENE DERIVATIVES USEFUL FOR TREATING PEPTIC ULCERS

• US 3,855,406 A
• Filed: 04/19/1973
• Issued: 12/17/1974
• Est. Priority Date: 09/02/1966
• Status: Expired due to Term

• Current Assignee: Boots Company PLC (Walgreens Boots Alliance Incorporated)
• Original Assignee: Bernard John Armitage, Bernard Vincent Heathcote, Norman William Bristow, Stuart Sanders Adams
• Inventors: Adams, Stuart Sanders, Armitage, Bernard John, Bristow, Norman William, Heathcote, Bernard Vincent
• Primary Examiner(s): Waddell, Frederick E.
• Application Number:
  US05/352,504
• Time in Patent Office: 607 Days
• Field of Search: 424/275
• US Class Current: 424/452
• CPC Class Codes: A61K 31/38 having sulfur as a ring hetero atom

Abstract

N-Hydroxy-N-9-thiaxanthenylurea, its esters and substituted derivatives thereof are useful in the treatment of peptic ulcer. Pharmaceutical compositions thereof and method of treating therewith also disclosed.

Claims

1. A THERAPEUTIC COMPOSITION USEFUL FOR TREATING PEPTIC ULCERS WHICH COMPRISES AN EFFECTIVE ANTI-SECRETORY AMOUNT OF A THIAXANTHEN COMPOUND OF THE FORMULA

2. The composition of claim 1 wherein Ro is hydRogen and R1 is hydroxy.

3. The composition of claim 1 wherein Ro is alkoxy and R1 is hydroxy.

4. The composition of claim 1 in the form of a tablet or capsule.

5. The composition of claim 4 wherein the said composition is enteric coated.

6. The composition of claim 4 wherein said composition contains 25-500 mg. of the thiaxanthen compound.

7. The composition of claim 1 in the form of a suppository.

8. The composition of claim 1 wherein said thiaxanthen compound is N-hydroxy-N-9-thiaxanthenylurea.

9. The composition of claim 1 in the form of an enteric coated tablet or capsule useful for treating peptic ulcer comprising 25-500 mg. of N-hydroxy-N-9-thiaxanthenylurea and a pharmaceutically acceptable excipient.

10. A method of treating peptic ulcer which comprises administering to a patient in need of said treatment a therapeutically effective anti-secretory amount of a thiaxanthen compound of the formula

11. The method of claim 10 wherein said thiaxanthen compound is administered orally.

12. The method of claim 10 wherein said thiaxanthen compound is administered at a dosage rate of 0.025-2 grams per day.

13. The method of claim 10 wherein said thiaxanthen compound is N-hydroxy-N-9-thiaxanthenylurea.