SOMATOSTATIN AS STIMULANT OF LUTEINIZING HORMONE SECRETION

• US 3,863,008 A
• Filed: 06/11/1973
• Issued: 01/28/1975
• Est. Priority Date: 06/11/1973
• Status: Expired due to Term

• Current Assignee: Norman H. Grant
• Original Assignee: Norman H. Grant
• Inventors: Grant, Norman H.
• Primary Examiner(s): Gotts, Lewis
• Assistant Examiner(s): Suyat, Reginald J.
• Application Number:
  US05/368,557
• Time in Patent Office: 596 Days
• Field of Search: 260/112.5 424/177
• US Class Current: 514/10.1
• CPC Class Codes: C07K 14/655 Somatostatins
• CPC Class Codes: Y10S 930/16 Somatostatin; related peptides

Abstract

Somatostatin and its linear counterpart are described as stimulating the release of luteinizing hormone.

Claims

2. A method according to claim 1 wherein said material of formula I is obtained from hypothalamic tissue.

3. A method according to claim 1 wherein in said protecting group linked to the sulfhydryl moiety is carboxymethyl.

4. A method of stimulating the release of luteinizing hormone in a warm blooded mammal which comprises administering to said mammal an effective amount for stimulating luteinizing hormone secretion of a material selected from the class consisting of H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, H-Ala-Gly-Cys(S-CH2-COOH)-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys(S -CH2COOH)-OH and the non-toxic acid addition salts thereof, said material being administered either orally, intravenously, subcutaneously or intramuscularly.

5. A method according to claim 4 wherein said material is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH.

6. A method according to claim 4 wherein said material is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH.