DERIVATIVES OF 1,3-DISUBSTITUTED 2,4(1H,3H)-QUINAZOLINEDIONES
0 Assignments
0 Petitions
Accused Products
Abstract
The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1(alky(alkylamino))-, 1-(alkylpiperidyl)-, 3-(alkyl(alkylamino))-, 3-(alkyl(4-phenyl-1-piperidyl)-, and 3-(alkyl(4-phenyl-1piperazinyl))-moieties. In the latter two substituents the phenyl group optionally is substituted with halogeno or loweralkyl groups. Additionally, the compounds optionally are substituted at carbon atoms 5 through 8 of the quinazolinedione nucleus with halogeno, nitro, alkoxy, and alkylamido substituents.
51 Citations
16 Claims
-
1. A compound having the formula
-
2. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-m-chlorophenyl-1-piperazyl)propyl) -2,4-(1H, 3H)quinazolinedione dihydrochloride.
-
3. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-phenyl-1 -piperazinyl)propyl)2,4(1H,3H)-quinazolinedione dehydrochloride.
-
4. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(3-(4-phenyl-1-piperidyl)propyl) -2,4(1H,3H)-quinazolinedione dihydrochloride.
-
5. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3(2-(4-phenyl-1 -piperazinyl)ethyl)2,4(1H,3H)-quinazolinedione dioxalate.
-
6. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(6-(4-phenyl-1-piperazinyl)hexyl) -2,4(1H,3H)-quinazolinedione dioxalate.
-
7. The compound as in claim 1, 61-(3-(N,N-di-methylamino)propyl)-3-(3-(4-phenyl-1-piperazyl) -2,4-(1H3H)quinazolinedione dioxalate.
-
8. The compound as in claim 1, 6-nitro-1-(3-(N,N-di-methylamino)propyl)-3-(3-(4-phenyl-1piperazinyl) -propyl)-2,4(1H, 3H)quinazolinedione dihydrochloride hydrate.
-
9. The compound is as in claim 1, 1-3-(1-piperidyl)-propyl)-3-(3-(4-phenyl-1-piperazinyl)propyl)-2,4-(1H,3H) -quinazolinedione dioxalate.
-
10. The compound as in claim 1, 1-(2-(N,N-dimethylamino)-ethyl)-3-(3-(4-phenyl-1 -piperazinyl(propyl)2,4(1H,3H)-quinazolinedione dioxalate.
-
11. The compound as in claim 1, 6-acetamido-1-(3-N,N-dimethylamino)propyl)-3-(3-(4-phenyl-1-piperazinyl) -propyl)-2, 4(1H,3H)quinazolinedione dioxalate hydrate.,
-
12. The compound as in claim 1, 1-(3-(N,N-diethylamino)-propyl)-3-(3-(4-phenyl-1 -piperazinyl)propyl)2,4(1H,3H)-quinazoLinedione dioxalate hydrate.
-
13. The compound as in claim 1, 6,7-dimethoxy-1(3-(N,N-dimethylamino)propyl)-3-(3-(4-phenyl-1-piperazyl) -propyl)-2,4-(1H,3H)quinazolinedione dihydrochlroide.
-
14. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(3-4o-methylphenyl-1-piperazinyl)-propyl)-2,3(1H, 3H)quinazolinedione.
-
15. The compound as in claim 1, 1-(3-(N,N-dimethylamino)-propyl)-3-(7-(4-phenyl-1-piperazinyl)heptyl)-2,4 -(1H, 3H)Quinazolinone dioxalate methanolate.
-
16. The compound as in claim 1, 1-(3-(1-piperidyl)propyl)-3-(6-(4-phenyl-1-piperazinyl)hexyl) -2,4(1H,3H)quinazolinedione dioxalate.
Specification