Piperidines
First Claim
1. A compound selected from the group consisting of bases of the formula:
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Abstract
This invention relates to novel heterocyclic compounds having the formula:
WHEREIN Ar represents a phenylene radical; A is selected from the group consisting of lower alkylene, mono-keto lower alkylene and hydroxy lower alkylene radicals, in all of which the lower alkylene portion contains from 1 to 6 carbon atoms; R is selected from the group consisting of cyclohexyl and substituted or unsubstituted phenyl radicals; and R1 and R2 are the same, or different, and are selected from the group consisting of hydrogen and alkyl radicals of 1 to 6 carbon atoms which may be straight chain or branched; or R1 and R2 together with the nitrogen atom to which they are attached represent a heterocyclic ring of 4 to 6 carbon atoms; and the acid addition and quaternary ammonium salts thereof; which exhibit action on the cardiovascular system, in particular Alpha -adrenoceptor antagonism. The invention also concerns pharmaceutical compositions containing the heterocyclic compounds of formula I.
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Citations
10 Claims
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1. A compound selected from the group consisting of bases of the formula:
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2. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-(N-isopropylamino)propoxy)phenyl-4 -oxobutyl)piperidine.
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3. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-(N-t-butylamino)propoxy))phenyl-4 -oxobutyl)piperidine.
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4. A compound as claimed in claim 1 which is 4-(p-chlorobenzamido)-1-(4-(4-(2-hydroxy-3-(N-isopropylamino) propoxy))phenyl-4-oxobutyl)piperidine.
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5. A compound as claimed in claim 1 which is 4-(m-methoxybenzamido)-1-(4-(4-(2-hydroxy-3-(N-isopropylamino) propoxy))-phenyl-4-oxobutyl)piperidine.
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6. A compound as claimed in claim 1 which is 4-cyclohexanecarboxamido-1-(4-(4-(2-hydroxy-3-(N-isopropylamino) propoxy))-phenyl-4-oxobutyl)piperidine.
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7. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-(N-methyl-N-isopropylamino)propoxy))phenyl -4-oxobutyl)piperidine.
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8. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-piperidinopropoxy))phenyl-4-oxobutyl) -piperidine.
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9. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy))phenyl-4 -oxobutyl)piperidine.
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10. A compound as claimed in claim 1 which is 4-benzamido-1-(4-(4-(2-hydroxy-3-(N-isopropylamino)propoxy))phenyl-4 -hydroxybutyl)piperidine.
Specification