POLYMERIC ARTICLE FOR DISPENSING DRUGS

• US 3,880,991 A
• Filed: 12/29/1970
• Issued: 04/29/1975
• Est. Priority Date: 03/24/1969
• Status: Expired due to Term

• Current Assignee: Seymour Yolles
• Original Assignee: Seymour Yolles
• Inventors: Yolles, Seymour
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/102,432
• Time in Patent Office: 1,582 Days
• Field of Search: 128/130,131,260 424/14,16,19,22,28,78-83,239
• US Class Current: 424/432
• CPC Class Codes: A61K 9/0039 Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence

Abstract

An article for dispensing drugs is disclosed which is formed from a crystalline polymeric material having a melting point of at least about 100*C. and a drug. The drug is dispersed throughout the polymer and the combination is formed into a solid shape having structural integrity.

Claims

1. AN INTRAUTERINE DEVICE FOR CONTROLLABLY DISPENSING AN EFFECTIVE CONTRACEPTIVE AMOUNT OF A PROGESTIN AND AN ESTROGEN COMPRISING A MOLDED SOLID SHAPED INTRAUTERINE DEVICE HAVING STRUCTURAL INTEGRITY CONTAINING AN EFFECTIVE INTRAUTERINE DOSAGE AMOUNT EACH OF PROGESTIN AND AN ESTROGEN IN COMBINSTION UNIFORMLY AND INTIMATELY DISPERSED THROUGHOUT A CRYSTALLINE POLYETHYLENE RESIN.

2. The device of claim 1 wherein the progestin is norethindrone and the estrogen is mestranol.

3. A method for preventing contraception which comprises inserting into the uterus an intrauterine device for controllably dispensing an effective contraceptive amount of a progestin and an estrogen comprising a molded solid shaped intrauterine device having structural integrity containing an effective intrauterine dosage amount each of a progestin and an estrogen in combination uniformly and intimately dispersed throughout a crystalline polyethylene resin.

4. The method of claim 3 for preventing contraception wherein the progestin in the uterine article is norethindrone and the estrogen is mestranol.