Surgical synthetic-resin material and method of treating osteomyelitis

• US 3,882,858 A
• Filed: 04/17/1974
• Issued: 05/13/1975
• Est. Priority Date: 04/21/1973
• Status: Expired due to Term

• Current Assignee: Klaus Klemm
• Original Assignee: Klaus Klemm
• Inventors: Klemm, Klaus
• Primary Examiner(s): Frinks, Ronald L.
• Application Number:
  US05/461,654
• Time in Patent Office: 391 Days
• Field of Search: 128/92G,92R,92C,92CA,92BC,1R,334R 3/1 32/1A
• US Class Current: 606/76
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08K 5/0058 Biocides; macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical

Abstract

Osteomyelitis is treated by filling an osteomyelitic cavity with particles of 1-20 mm diameter of a polymethacrylate, polyacrylate or copolymer thereof which is impregnated with gentamycin or other antibiotic. Particles of such antibiotic impregnated polymer joined together by a thread or wire are particularly useful for this purpose.

Claims

1. A METHOD OF TREATING OSTEROMYELITIS WHICH COMPRISES IMPLANTING IN AN OSTEROMYELITIC ACITY STERILE PARTICLES HAVING A DIAMETER OF 1 - 20 MM. OF A SOLID PHYSIOLOGICALLY ACCEPTABLE BONE CEMENT IMPREGNATED WITH AT LEAST ONE TOPICAL EFFECTIVE ANTIBIOTIC.

2. A method according to claim 1 wherein the particles have a diameter of 5-15 mm.

3. A method according to claim 1 wherein the bone cement is consisting essentially of polymethacrylate, a polyacrylate or copolymer thereof.

4. A method according to claim 3 wherein the particles are a copolymer of methyl methacrylate and methyl acrylate.

5. A method according to claim 1 wherein the antibiotic is gentamycin.

6. A method according to claim 1 wherein the particles are impregnated with about 0.2 - 15 percent by weight of antibiotic.

7. A method according to claim 1 wherein the particles are impregnated with about 1-4 percent by weight of gentamycin, calculated as gentamycin base.

8. A method according to claim 1 wherein individual particles of the polymer are connected by a surgically acceptable thread or wire.

9. A method according to claim 8 wherein the particleS have a diameter of 5-15 mm. and are joined together by a surgically acceptable thread or wire.

10. A surgical device adapted for implantation into a wound comprising particles of a solid physiologically acceptable bone cement impregnated with an antibiotic joined together by a physiologically acceptable thread or wire.

11. A surgical device according to claim 10 wherein the particles have a diameter of 5-15 mm.

12. A surgical device according to claim 10 wherein the bone cement is consisting essentially of polymethacrylate, polyacrylate or copolymer thereof.

13. A surgical device according to claim 10 wherein the antibiotic is gentamycin.

14. A surgical device according to claim 10 wherein the particles are impregnated with about 0.2 - 15 percent by weight of antibiotic.

15. A surgical device according to claim 10 wherein the particles are impregnated with about 1-4 percent by weight of gentamycin, calculated as gentamycin base.