Process for the manufacture of insulin, analogs and derivatives thereof

• US 3,883,500 A
• Filed: 10/29/1973
• Issued: 05/13/1975
• Est. Priority Date: 10/31/1972
• Status: Expired due to Term

• Current Assignee: Georg Jager, Rolf Geiger
• Original Assignee: Georg Jager, Rolf Geiger
• Inventors: Geiger, Rolf, Jager, Georg
• Primary Examiner(s): Gotts, Lewis
• Assistant Examiner(s): Suyat, Reginald J.
• Application Number:
  US05/410,310
• Time in Patent Office: 561 Days
• Field of Search: 260/112.7,112.5
• US Class Current: 530/303
• CPC Class Codes: C07K 14/62 Insulins
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
• CPC Class Codes: Y10S 930/26 Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Abstract

D R A W I N G
A method for making insulin and certain derivatives thereof from a compound of the formula (I)

D R A W I N G
wherein X is hydrogen or an S-protective group and n is an integer from two to four, which comprises cleaving any Sprotective groups present and dehydrogenating -SH groups to form S-S bonds to form a compound of the formula (II)

BRIDGE BY TREATING THE LATTER COMPOUND WITH AN ACID. Compounds of the formula II.

and then eliminating the

Claims

1. A METHOD FOR MAKING AN INSULIN COMPOUND OF THE FORMULA

2. An insulin compound of the formula