Process for the manufacture of insulin, analogs and derivatives thereof
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Abstract
BRIDGE BY Edman degradation. Compounds of the formula II.
A method for making insulin and certain derivatives thereof from a compound of the formula(I)
wherein Ac is an N-protective group removable by proton solvolysis X is hydrogen or an S-protective group, and n is 2 or 3, which comprises solvolyzing the Ac groups and dehydrogenating the -SX groups to S-S bonds to form a compound of the formula (II)
and then eliminating the
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2 Claims
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1. A METHOD FOR MAKING AN INSULIN COMPOUND OF THE FORMULA
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2. An insulin compound of the formula
Specification