1-[1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl]-2-benzimidazolinones and related compounds

• US 3,894,030 A
• Filed: 02/06/1974
• Issued: 07/08/1975
• Est. Priority Date: 01/04/1973
• Status: Expired due to Term

• Current Assignee: Ineke Van Wijngaarden, Paul Adriaan Jan Janssen, Willem Soudijn
• Original Assignee: Ineke Van Wijngaarden, Paul Adriaan Jan Janssen, Willem Soudijn
• Inventors: Janssen, Paul Adriaan Jan, Soudijn, Willem, Wijngaarden, Ineke Van
• Primary Examiner(s): Todd, G. Thomas
• Application Number:
  US05/459,500
• Time in Patent Office: 517 Days
• Field of Search: 260/293.6,294.9C,295K
• US Class Current: 546/199
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond

Abstract

Compounds of the class of 1-(1-(2-hydroxy-3-aryloxypropyl)-4piperidyl)- and 1-(1,2,3,6-tetrahydro-1-(2-hydroxy-3aryloxypropyl)-4-pyridyl)-2 -benzimidazolinones, useful as antihypertensive agents.

Claims

1. A CHEMICAL COMPOUND SELECTED FROM THE GROUP CONSISTING OF A BENZIMIDAZOLINE DERIVATIVE HAVING THE FORMULA:

2. A chemical compound selected from the group consisting of a benzimidazoline derivative having the formula:

3. A chemical compound selected from the group consisting of a benzimidazoline derivative having the formula:

4. A compound selected from the group consisting of 1-(1-(3-(o-cyanophenoxy)-2-hydroxypropyl)-4-piperidyl)-2-benzimidazolinone and the therapeutically active acid addition salts thereof.

5. A compound selected from the group consisting of methyl o-(2-hydroxy-3-(4-(2-oxo-1-benzimidazolinyl)piperidino)propoxy)benzoate and the therapeutically active acid addition salts thEreof.