Ansa Macrolides

• US 3,896,111 A
• Filed: 02/20/1973
• Issued: 07/22/1975
• Est. Priority Date: 02/20/1973
• Status: Expired due to Term

• Current Assignee: Gareth J. Thomas, Kupchan S. Morris, William A. Court, Yasuo Komoda
• Original Assignee: Gareth J. Thomas, Kupchan S. Morris, William A. Court, Yasuo Komoda
• Inventors: Kupchan, S. Morris, Komoda, Yasuo, Thomas, Gareth J., Court, William A.
• Primary Examiner(s): Jiles, Henry R.
• Assistant Examiner(s): Bond, Robert T.
• Application Number:
  US05/333,940
• Time in Patent Office: 882 Days
• Field of Search: 260/239.3P,239.3T 424/248
• US Class Current: 540/462
• CPC Class Codes: C07D 498/18 Bridged systems

Abstract

There are provided Novel Ansa Macrolides derived from Maytenus Buchananii (Loes.) Wilczek and Maytenus ovatus. which possess high and surprising antileukaemic activity against P-388 lymphocytic leukemia in test animals at dosage levels of micrograms per kilogram body weight.

Claims

1. A COMPOUND SELECTED FROM THE GROUP HAVING THE FORMULA:

2. Maytansine, being a compound of claim 1 wherein R is -CH3.

3. Maytansine, Mayatansine, being a compound of claim 1 wherein R is -CH2 CH3.

4. Maytanbutine being a compound of claim 1 wherein R is CH(CH3)2.