1-(Naphthylalkyl- or indenylalkyl)-piperidines
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Abstract
A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial deep allergic phenomena is described. These are piperidine compounds linked by naphthyl, 1,2,3,4tetrahydronaphthyl or idenyl radicals through the intermediary of a group selected from a lower-alkylene radical, a mono- -keto lower-alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula
or -O(lower-alkylene)-. The ring is further substituted by an amino or acylamino residue.
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Citations
12 Claims
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1. A HETEROCYCLIC COMPOUND OF THE FORMULA:
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2. A compound as claimed in claim 1 which is 1-(2-(2-naphthyl) ethyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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3. A compound as claimed in claim 1 which is 1-(3-(1-naphthyloxy)-propyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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4. A compound as claimed in claim 1, which is 1-(3-(1-naphthoxy)-2-hydroxy-prop-1-yl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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5. A compound as claimed in claim 1 which is 1-(2-(1,2,3,4-tetrahydro-6-naphthyl)-2-hydroxyethyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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6. A compound as claimed in claim 1, which is 1-(4-(1,2,3,4-tetrahydro-6-naphthyl)-4-oxobutyl)-4-benzamido-piperidine or a pharmaceutically acceptable acid addition salt thereof.
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7. A compound as claimed in claim 1, which is 7-(2-(4-benzamidopiperid-1-yl)-1-hydroxyethyl)-1,1,3,4,4,6-hexamethyl-1, 2,3,4-tetrahydronaphthalene or a pharmaceutically acceptable acid addition salt thereof.
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8. A compound as claimed in claim 1, which is 1-(4-(1'"'"''"'"',2'"'"''"'"',3'"'"''"'"',4'"'"''"'"'-tetrahydro-6'"'"''"'"'-naphthyl)-4-hydroxybutyl)-4 -benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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9. A compound as claimed in claim 1 which is 1-(4-(2-naphthyl)-4-oxobutyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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10. A compound as claimed in claim 1, which is 1-(4-(1'"'"''"'"',2'"'"''"'"',3'"'"''"'"', 4'"'"''"'"'-tetrahydro-6-naphthyl)butyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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11. A compound as claimed in claim 1, which is 1-(4-(2'"'"''"'"'-Naphthyl)-4-hydroxybutyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.
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12. A compound as claimed in claim 1, which is 1-(3-(3-indenyl)propyl)-4-benzamidopiperidine.
Specification