1-(Naphthylalkyl- or indenylalkyl)-piperidines

• US 3,910,931 A
• Filed: 11/15/1974
• Issued: 10/07/1975
• Est. Priority Date: 09/03/1970
• Status: Expired due to Term

• Current Assignee: John Frederick Cavalla, John Leheup Archibald
• Original Assignee: John Frederick Cavalla, John Leheup Archibald
• Inventors: Cavalla, John Frederick, Archibald, John Leheup
• Primary Examiner(s): Winters, Sherman D.
• Application Number:
  US05/524,162
• Time in Patent Office: 326 Days
• Field of Search: 260/293.62
• US Class Current: 546/206
• CPC Class Codes: C07C 45/63 by introduction of halogen; by substitution of halogen atoms by other halogen atoms
• CPC Class Codes: C07C 49/813 polycyclic
• CPC Class Codes: C07D 211/58 attached in position 4
• CPC Class Codes: C07D 211/72 with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
• CPC Class Codes: C07D 213/75 Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
• CPC Class Codes: C07D 333/16 by oxygen atoms
• CPC Class Codes: C07D 333/56 Radicals substituted by oxygen atoms

Abstract

A group of heterocyclic compounds useful in the treatment of disorders and diseases of the cardiovascular system and/or in the treatment of superficial deep allergic phenomena is described. These are piperidine compounds linked by naphthyl, 1,2,3,4tetrahydronaphthyl or idenyl radicals through the intermediary of a group selected from a lower-alkylene radical, a mono- -keto lower-alkylene radical or a hydroxy-lower-alkylene radical, or a bivalent radical of the formula

or -O(lower-alkylene)-. The ring is further substituted by an amino or acylamino residue.

Claims

1. A HETEROCYCLIC COMPOUND OF THE FORMULA:

2. A compound as claimed in claim 1 which is 1-(2-(2-naphthyl) ethyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

3. A compound as claimed in claim 1 which is 1-(3-(1-naphthyloxy)-propyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

4. A compound as claimed in claim 1, which is 1-(3-(1-naphthoxy)-2-hydroxy-prop-1-yl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

5. A compound as claimed in claim 1 which is 1-(2-(1,2,3,4-tetrahydro-6-naphthyl)-2-hydroxyethyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

6. A compound as claimed in claim 1, which is 1-(4-(1,2,3,4-tetrahydro-6-naphthyl)-4-oxobutyl)-4-benzamido-piperidine or a pharmaceutically acceptable acid addition salt thereof.

7. A compound as claimed in claim 1, which is 7-(2-(4-benzamidopiperid-1-yl)-1-hydroxyethyl)-1,1,3,4,4,6-hexamethyl-1, 2,3,4-tetrahydronaphthalene or a pharmaceutically acceptable acid addition salt thereof.

8. A compound as claimed in claim 1, which is 1-(4-(1'"'"''"'"',2'"'"''"'"',3'"'"''"'"',4'"'"''"'"'-tetrahydro-6'"'"''"'"'-naphthyl)-4-hydroxybutyl)-4 -benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

9. A compound as claimed in claim 1 which is 1-(4-(2-naphthyl)-4-oxobutyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

10. A compound as claimed in claim 1, which is 1-(4-(1'"'"''"'"',2'"'"''"'"',3'"'"''"'"', 4'"'"''"'"'-tetrahydro-6-naphthyl)butyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

11. A compound as claimed in claim 1, which is 1-(4-(2'"'"''"'"'-Naphthyl)-4-hydroxybutyl)-4-benzamidopiperidine or a pharmaceutically acceptable acid addition salt thereof.

12. A compound as claimed in claim 1, which is 1-(3-(3-indenyl)propyl)-4-benzamidopiperidine.