Process for producing dopa preparation
First Claim
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1. A PROCESS FOR PRODUCING A L-DOPA PREPARATION WHICH COMPRISES REACTING AN L-DOPA WITH AT LEAST ONE NON-TOXIC POLYVALENT METAL SALT OF A CHLORIDE, IODINE, BROMIDE, SULFATE, PHOSPHATE OR NITRATE AND THE METAL OF WHICH CA, CO, MN, ZN, OR MG.
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Abstract
A dopa preparation can be produced by dissolving a dopa in water and adding to the resulting aqueous solution at least one nontoxic polyvalent metal salt or an aqueous solution thereof to form a complex compound.
23 Citations
14 Claims
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1. A PROCESS FOR PRODUCING A L-DOPA PREPARATION WHICH COMPRISES REACTING AN L-DOPA WITH AT LEAST ONE NON-TOXIC POLYVALENT METAL SALT OF A CHLORIDE, IODINE, BROMIDE, SULFATE, PHOSPHATE OR NITRATE AND THE METAL OF WHICH CA, CO, MN, ZN, OR MG.
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2. A process according to claim 1, wherein a reaction product of a dopa with said non-toxic polyvalent metal salt is obtained as a highly concentrated solution.
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3. A process according to claim 1, wherein a reaction product of a dopa with said non-toxic polyvalent metal salt is separated as an amorphous complex compound.
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4. The process of claim 1 wherein the metal is Ca.
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5. The process of claim 1 wherein the metal is Co.
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6. The process of claim 1 wherein the metal is Mn.
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7. The process of claim 1 wherein the metal is Zn.
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8. The process of claim 1 wherein the metal is Mg.
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9. An amorphous complex of an L-dopa and Ca, Co, Mn, Zn or Mg.
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10. A Ca complex of claim 9.
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11. A Co complex of claim 9.
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12. An Mn complex of claim 9.
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13. A Zn complex of claim 9.
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14. A Mg complex of claim 9.
Specification
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Current AssigneeKunihiro Sasahara, Ryuzo Okada, Takasi Nitanai
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Original AssigneeKunihiro Sasahara, Ryuzo Okada, Takasi Nitanai
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InventorsOkada, Ryuzo, Nitanai, Takasi, Sasahara, Kunihiro
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Primary Examiner(s)Sneed, Helen M. S.
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Application NumberUS05/419,391Time in Patent Office700 DaysField of Search260/438.1,429.9,519,448,429US Class Current556/26CPC Class CodesA61K 31/198 Alpha-amino acids, e.g. ala...
