Compositions comprising d-thyroxine and d-triiodothyronine

• US 3,917,832 A
• Filed: 09/24/1971
• Issued: 11/04/1975
• Est. Priority Date: 05/28/1971
• Status: Expired due to Term

• Current Assignee: Franz Adolf Horster
• Original Assignee: Franz Adolf Horster
• Inventors: Horster, Franz Adolf
• Primary Examiner(s): Waddell, Frederick E.
• Application Number:
  US05/183,663
• Time in Patent Office: 1,502 Days
• Field of Search: 424/319
• US Class Current: 514/567
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00

Abstract

Pharmaceutical compositions comprising d-thyroxine and dtriiodothyronine are useful in the treatment of hyperlipidemias, especially hypercholesterolemias and hypertriglyceridemias.

Claims

1. A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HYPERLIPIDEMIA COMPRISING, PER UNIT DOSAGE, 0.2 -4 MG OF D-THYROXINE OR A PHYSIOLOGICALLY ACCEPTABLE SALT THEREOF AND 0.05 -1 MG. OF D-TRIIODOTHYRONINE OR A PHYSIOLOGICALLY ACCEPTABLE SALT THEREOF, IN A WEIGHT RATIO OF THE FORMER TO THE LATTER OF ABOUT 4:

1, AND AT LEAST ONE SOLID, LIQUID OR SEMI-LIQUID PHARMACEUTICALLY ACCEPTABLE CARRIER.

2. The composition of claim 1 adapted for oral ingestion containing, per unit dosage, 0.5 - 2 mg. of d-thyroxine or a physiologically acceptable salt thereof and 0.1 - 0.5 mg. of d-triiodothyronine or a physiologically acceptable salt thereof.

3. A method for the treatment of hyperlipidemia in a living being which comprises administering thereto a composition according to claim 1 in a daily dosage of 0.2 - 4 mg. of said d-thyroxine or a physiologically acceptable salt thereof and 0.05 -1 mg. of said d-triiodothyronine or a physiologically acceptable salt thereof over a period of at least several weeks to lower both blood cholesterol and lipid levels.

4. A method according to claim 3 wherein the sodium salt of d-thyroxine and the sodium salt of d-triiodothyronine are administered to a living human being.