Pharmaceutical devices and method

• US 3,920,805 A
• Filed: 12/17/1973
• Issued: 11/18/1975
• Est. Priority Date: 12/09/1971
• Status: Expired due to Term

• Current Assignee: Theodore J. Roseman
• Original Assignee: Theodore J. Roseman
• Inventors: Roseman, Theodore J.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/425,600
• Time in Patent Office: 701 Days
• Field of Search: 128/260,130 424/19-22,15
• US Class Current: 424/432
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61K 9/0036 Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
• CPC Class Codes: A61K 9/2036 Silicones; Polysiloxanes
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A solid pharmaceutical device formed of a nontoxic resilient polymer and medication releasable therefrom during residence in a living mammal. The device has a nonmedicated core of the polymer encircled by a medicated coating of the polymer. Reduced content of diffusible medication is achieved.

Claims

1. A SOLID PHARMACEUTICAL DEVICE FORMED AS A VAGINAL RING OF A NONTOXIC RESILIENT MEDICATON DIFFUSING ORGANOPOLYSILOXANE POLYMER AND AN EFFECTIVE VAGINAL DOSAGE AMOUNT OF A MEDICATION DIFFUSIBLE THEREIN WHICH RELEASES SAID MEDICATION DURING RESIDENCE IN THE VAGINAL CAVITY OF A LIVING MAMMAL CONSISTING ESSENTIALLY OF, IN COMBINATION, A NONMEDICATED CENTRAL CORE OF SAID POLYMER AND AN ENCIRCLING FINITE THICKNESS OF A MEDICATED COATING OF SAID POLYMER.

2. The device of claim 1 which is formed of dimethylpolysiloxane with a centered metallic, endless, helical or flat tensioning spring molded in the nonmedicated central core and the diffusible medication is medroxyprogesterone acetate.