Method for incorporating substances into protein microspheres
First Claim
1. A process for incorporating a substance capable of being precipitated into albumin millimicrospheres comprising:
- preparing a precipitate of said substance and forming a mixture of the precipitate with an aqueous solution of albumin;
injecting said mixture into oil and pressing the resultant through a fine capillary or rotating disc to form an extremely fine emulsion of droplets of the precipitate and albumin in said oil, heating said oily mixture above 100°
C and separating the formed albumin millimicrospheres from said oil having said precipitate encapsulated therein.
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Abstract
The subject matter of this invention is a process for solid albumin particles so that such spheric particles may act as a carrier for radioactivity, drugs, insecticides, dyes, metal salts, etc. In order to prepare such spheric particles, the substance to be incorporated therein is transformed into a precipitate. This precipitate is then mixed with an aqueous solution of albumin. The mixture thus prepared is then injected into cotton seed oil while stirring so as to obtain a fine dispersion of the albumin droplets and the precipitate in the oil, then the mixture is heated above 100°C to evaporate water and to form spheric albumin particles having the precipitate encapsulated therein.
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Citations
1 Claim
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1. A process for incorporating a substance capable of being precipitated into albumin millimicrospheres comprising:
- preparing a precipitate of said substance and forming a mixture of the precipitate with an aqueous solution of albumin;
injecting said mixture into oil and pressing the resultant through a fine capillary or rotating disc to form an extremely fine emulsion of droplets of the precipitate and albumin in said oil, heating said oily mixture above 100°
C and separating the formed albumin millimicrospheres from said oil having said precipitate encapsulated therein.
- preparing a precipitate of said substance and forming a mixture of the precipitate with an aqueous solution of albumin;
Specification
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- Resources
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Current AssigneeIlse Zolle
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Original AssigneeIlse Zolle
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InventorsZolle, Ilse
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Primary Examiner(s)Lovering, Richard D.
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Application NumberUS05/304,218Time in Patent Office1,191 DaysField of Search252/316, 252/301.1 R, 424/1, 424/2, 424/36, 424/37, 424/19, 424/178, 264/.5, 117/100 AUS Class Current424/1.29CPC Class CodesA01N 25/28 Microcapsules or nanocapsulesA61K 9/1658 Proteins, e.g. albumin, gel...B01J 13/02 Making microcapsules or mic...Y10S 436/829 Liposomes, e.g. encapsulationY10T 428/2984 Microcapsule with fluid cor...
