Controlled release delivery system by an osmotic bursting mechanism

• US 3,952,741 A
• Filed: 01/09/1975
• Issued: 04/27/1976
• Est. Priority Date: 01/09/1975
• Status: Expired due to Term

• Current Assignee: Bend Research Inc. (Lonza Group AG)
• Original Assignee: Bend Research Inc. (Lonza Group AG)
• Inventors: Baker, Richard William
• Primary Examiner(s): Medbery, Aldrich F.
• Application Number:
  US05/539,637
• Time in Patent Office: 474 Days
• Field of Search: 222/95, 222/92, 222/167, 222/153, 222/541, 222/54, 222/491, 424/19, 424/20, 128/260, 128/272
• US Class Current: 424/405
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: B65D 65/38 Packaging materials of special type or form

Abstract

An osmotic dispenser comprised of (1) a water permeable membrane forming part or all of the walls of an enclosure surrounding (2) an active agent, and in some cases (3) an additional compound known as an osmotic attractant which together exhibits an osmotic pressure against water. When placed in an aqueous environment water is osmotically drawn into the enclosure by the combined action of the agents (2) and (3) which distends and swells the enclosure until the membrane or some other part of the enclosure wall reaches the point of ultimate elongation and a portion of the wall yields and ruptures releasing the contents of the enclosure to the environment.

Claims

1. A water actuated osmatic type active agent dispenser including a means for dispensing a dosage of active agent into an aqueous fluid or humid environment comprising (1) a fluid permable membrane defining at least a part of a walled enclosure, said enclosure containing therein an active agent which exhibits an osmatic pressure upon exposure of the enclosure to the environment, the thickness and permibility of said membrane comprising a means for controlling the water diffusion therethrough until the osmotic pressure in the enclosure is sufficient to distort, stretch and finally rupture the enclosure resulting in release of the agent to the environment.

2. An osmotic dosage form comprising a plurality of dispensers as set forth in claim 1 wherein said membrane and agent combination is related in a progressive series over a predetermined range such that on prolonged exposure to said aqueous or humid environment the diffusion of water takes place at related varying rates causing the serial bursting of the individual dispensers.

3. An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is an herbicide.

4. An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is a pesticide, insecticide or larvicide.

5. An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is a fertilizer.

6. An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is an animal or human medicament.

7. An osmotic dosage form as set forth in claim 1 wherein at least a part of the agent is a medicament and the aqueous environment is the gastrointestinal fluid.

8. An osmotic dispenser as set forth in claim 1 wherein a portion of the agent (2) is a biologically or chemically active material and a portion of the agent is an osmotic attractant by means of which the rate of water diffusion into the enclosure and hence subsequent rupture of the enclosure can be regulated.

9. An osmotic dosage form comprising a plurality of dispensers as set forth in claim 8 wherein the membrane, or the osmotic attractant or a combination of these is related in a progressive series over a predetermined range such that on prolonged exposure to an aqueous or humid environment the diffusion of water takes place at related varying rates causing the serial bursting of the individual dispensers.

10. An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is an herbicide.

11. An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is a pesticide, insecticide or larvicide.

12. An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is a fertilizer.

13. An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is an animal or human medicament.

14. An osmotic dispenser as set forth in claim 1 wherein the enclosure wall contains a weak spot or seam which on exposure of the dispenser to the aqueous or humid environment and subsequent imbibition of water causes the enclosure wall to rupture at the weak spot or seam resulting in release of the agent to the environment at a time determined by the strength of the weak spot or seam.