Amino derivatives of thiazolo[5,4-b]pyridine-6-carboxylic acids and esters

• US 3,953,461 A
• Filed: 03/05/1975
• Issued: 04/27/1976
• Est. Priority Date: 03/05/1975
• Status: Expired due to Term

• Current Assignee: E R Squibb & Sons Incorporated
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Denzel, Theodor, Hoehn, Hans
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US05/555,512
• Time in Patent Office: 419 Days
• Field of Search: 260/294.8 C
• US Class Current: 546/114
• CPC Class Codes: C07D 213/80 in position 3
• CPC Class Codes: C07D 513/04 Ortho-condensed systems

Abstract

The new derivatives of thiazolo[5,4-b]pyridine-6-carboxylic acids, esters and their salts which have the general formula ##SPC1##

Are useful as central nervous system depressants and antiinflammatory agents.

Claims

1. A compound of the formula ##SPC8##

wherein R, R₁ and R₄ each is hydrogen or lower alkyl, and R₂ and R₃ each is hydrogen, lower alkyl, phenyl or di(lower alkyl)amino-lower alkyl, and physiologically acceptable salts thereof.

2. A compound as in claim 1 wherein R, R₁, R₂, R₃ and R₄ each is hydrogen or lower alkyl.

3. A compound as in claim 1 wherein R, R₁ and R₄ each is hydrogen or lower alkyl, R₂ is hydrogen and R₃ is di(lower alkyl)amino-lower alkyl.

4. A compound as in claim 1 wherein R, R₁ and R₂ each is lower alkyl and R₃ and R₄ each is hydrogen.

5. A compound as in claim 1 wherein R is ethyl, R₁ is methyl, R₂ is hydrogen, R₃ is butyl and R₄ is hydrogen.

6. A compound as in claim 1 wherein R is ethyl, R₁ and R₄ each is methyl, R₃ is butyl and R₂ is hydrogen.

7. A compound as in claim 1 wherein R is ethyl, R₁ and R₄ each is methyl, R₂ is hydrogen and R₃ is dimethylaminopropyl.

8. A compound as in claim 1 wherein R is ethyl, R₁ is methyl, R₂ and R₄ each is hydrogen and R₃ is dimethylaminopropyl.

9. A compound as in claim 1 wherein R is ethyl, R₁ is methyl, R₂ and R₄ each is hydrogen and R₃ is tert.butyl.