7-[(2-Oxo-1-pyridinyl)acylamino]cephalosporin derivatives
First Claim
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1. A compound having the formula:
- ##SPC15##in which either R1 or R2 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, trifluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy and carbethoxy;
R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, trifluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy, carbethoxy, and which when taken in combination with R2 forms the cyclic radical --CH2 CH2 CH2 CH2 -- and --CH=CH--CH=CH--;
R4 is selected from the group consisting of hydrogen, methyl, carboxy, carbomethoxy and carbethoxy;
R5 is ##EQU4## wherein X is hydrogen, hydroxy, acetoxy, N-pyridinium 5-methyl-1,3,4-thiadiazol-2-ylthio and 1-methyl-1,2,3,4-tetrazol-5-ylthio; and
the pharmaceutically acceptable salts thereof.
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Abstract
Novel [substituted(2-oxo-1-pyridinyl)acetylamino] penicillin and cephalosporin derivatives are prepared which are useful antibacterial agents.
14 Citations
5 Claims
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1. A compound having the formula:
- ##SPC15##
in which either R1 or R2 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, trifluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy and carbethoxy; R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkyl, trifluoromethyl, nitro, amino, cyano, carboxy, carbomethoxy, carbethoxy, and which when taken in combination with R2 forms the cyclic radical --CH2 CH2 CH2 CH2 -- and --CH=CH--CH=CH--; R4 is selected from the group consisting of hydrogen, methyl, carboxy, carbomethoxy and carbethoxy; R5 is ##EQU4## wherein X is hydrogen, hydroxy, acetoxy, N-pyridinium 5-methyl-1,3,4-thiadiazol-2-ylthio and 1-methyl-1,2,3,4-tetrazol-5-ylthio; and
the pharmaceutically acceptable salts thereof. - View Dependent Claims (2, 3, 4, 5)
- ##SPC15##
Specification
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Current AssigneeRichardson-Merrell Inc
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Original AssigneeRichardson-Merrell Inc
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InventorsEdwards, Michael L., Bambury, Ronald E., Miller, Laird F.
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Primary Examiner(s)Rizzo, Nicholas S.
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Application NumberUS05/413,566Time in Patent Office916 DaysField of Search260/243 CUS Class Current540/225CPC Class CodesC07D 213/64 attached in position 2 or 6C07D 499/00 Heterocyclic compounds cont...
