In vivo specific ion sensor
First Claim
1. An in vivo specific ion sensor which comprises a flexible metallic elongated electrode lead, an electrochemically active portion at one end thereof, a first immobilized electrolyte coating the electrochemically active portion, a membrane barrier selectively permeable to a particular ionic species encapsulating the electrochemically active portion and the electrolyte, electrical insulation surrounding and adhering to the electrode lead, an electrically-insulating irregularly-curved tube surrounding at least a portion of the electrode lead and electrically insulated therefrom, one end of the tube being disposed adjacent to and spaced from the membrane barrier and being closed by a second ion-permeable membrane, an aperture in the tube, a second immobilized electrolyte contained within the tube and in contact with the second ion-permeable membrane, a metallic reference electrode element partially within the tube comprising a metallic electrode lead and an electrochemically active region, the active region of the reference electrode being in contact with the second electrolyte, a portion of the metallic reference electrode element extending externally of the tube through the tube aperture, a seal closing the aperture around the reference electrode, and a seal closing the opposite end of the tube.
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Accused Products
Abstract
An in vivo specific ion sensor contains a specific ion electrode and surrounding reference half cell which has its immobilized electrolyte adjacent to and spaced from the specific ion electrode. The specific ion sensor is introduced, for example, into the blood stream by passing it through a cannula which perforates the subject'"'"'s tissue and the underlying wall of the blood vessel.
49 Citations
2 Claims
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1. An in vivo specific ion sensor which comprises a flexible metallic elongated electrode lead, an electrochemically active portion at one end thereof, a first immobilized electrolyte coating the electrochemically active portion, a membrane barrier selectively permeable to a particular ionic species encapsulating the electrochemically active portion and the electrolyte, electrical insulation surrounding and adhering to the electrode lead, an electrically-insulating irregularly-curved tube surrounding at least a portion of the electrode lead and electrically insulated therefrom, one end of the tube being disposed adjacent to and spaced from the membrane barrier and being closed by a second ion-permeable membrane, an aperture in the tube, a second immobilized electrolyte contained within the tube and in contact with the second ion-permeable membrane, a metallic reference electrode element partially within the tube comprising a metallic electrode lead and an electrochemically active region, the active region of the reference electrode being in contact with the second electrolyte, a portion of the metallic reference electrode element extending externally of the tube through the tube aperture, a seal closing the aperture around the reference electrode, and a seal closing the opposite end of the tube.
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2. An in vivo specific ion sensor which comprises a flexible metallic elongated electrode lead, an electrochemically active portion at one end thereof, a first immobilized electrolyte coating the electrochemically active portion, a membrane barrier selectively permeable to a particular ionic species encapsulating the electrochemically active portion and the electrolyte, electrical insulation surrounding and adhering to the electrode lead, a tube of electrically-insulating material surrounding at least a portion of the electrode lead and electrically insulated therefrom, one end of the tube being disposed adjacent to and spaced from the membrane barrier and being closed by a second ion-permeable membrane, a second immobilized electrolyte contained within the tube and in contact with the second ion-permeable membrane, an irregularly-curved metallic tube having one end sealed to the open end of the electrically-insulating tube and having an aperture to receive the electrode lead and adhering electrical insulation, an electrochemically active region on at least a portion of the inner surface of the metallic tube and in contact with the second electrolyte, a seal closing the aperture around the electrode lead, and a seal closing the other end of the metallic tube.
Specification