Surgical sutures of unsymmetrically substituted 1,4-dioxane-2,5-diones
First Claim
1. A method of closing a wound of living tissue which comprises:
- sewing the edges of the wound with a surgical suture consisting of at least one filament of polymer containing more than 2% by weight of recurring units of the formula;
##EQU18## and the remaining units are ##EQU19## and ##EQU20## wherein R1 and R2 are not the same as R3 and R4, R1 has at least one carbon atom, and R1, R2, R3, R4, R5, R6, R7 and R8 are separately selected from the group consisting of hydrogen, and the radicals methyl, ethyl, propyl, isopropyl, butyl, isobutyl, cyclohexyl, and phenyl,embedding the suture in living tissue andleaving the suture in said tissue until said suture is absorbed by the tissue during the healing process.
0 Assignments
0 Petitions
Accused Products
Abstract
Unsymmetrically 3,6-substituted 1,4-dioxane-2,5-diones may be polymerized to give living-tissue absorbable, hydrolytically degradable surgically useful polymers. These polymers have predominantly regular rather than random spacings of side chains, may be stereoregular and tend toward higher crystallinity than randomly sequenced polymers. A polymer of 3-methyl-1,4-dioxane-2,5-dione has the same empirical formula as an equimolecular copolymer of lactic and glycolic acid but has unique physical properties resulting from its more regular steric configuration. Polymers and copolymers of 3- and 3,6-unsymmetrically substituted 1,4-dioxane-2,5-diones have surgically useful mechanical properties. On implantation, in living mammalian tissue, the polymers are absorbed, and replaced by living tissue.
-
Citations
7 Claims
-
1. A method of closing a wound of living tissue which comprises:
-
sewing the edges of the wound with a surgical suture consisting of at least one filament of polymer containing more than 2% by weight of recurring units of the formula;
##EQU18## and the remaining units are ##EQU19## and ##EQU20## wherein R1 and R2 are not the same as R3 and R4, R1 has at least one carbon atom, and R1, R2, R3, R4, R5, R6, R7 and R8 are separately selected from the group consisting of hydrogen, and the radicals methyl, ethyl, propyl, isopropyl, butyl, isobutyl, cyclohexyl, and phenyl,embedding the suture in living tissue and leaving the suture in said tissue until said suture is absorbed by the tissue during the healing process. - View Dependent Claims (2, 3)
-
-
4. A method of retaining living tissue in a desired location and relationship during a healing process which comprises:
positioning and emplacing living tissue with a surgical element of polymer containing more than 2% by weight of recurring units of the formula;
##EQU24## and the remaining units are ##EQU25## and ##EQU26## where R1 and R2 are not the same as R3 and R4, R1 has at least one carbon atom, and R1, R2, R3, R4, R5, R6, R7 and R8 are separately selected from the group consisting of hydrogen, and the radicals methyl, ethyl, propyl, isopropyl, butyl, isobutyl, cyclohexyl, and phenyl,- View Dependent Claims (6, 7)
-
5. embedding said element in living tissue and
leaving said element in said tissue until said element is absorbed by the tissue during the healing process, the element retaining a high proportion of its original strength for at least three days and being substantially absorbed in about six months when the living tissue is muscular tissue, and a proportionate time in other tissues.
Specification