Automatic regulation of respirators

• US 3,961,627 A
• Filed: 09/03/1974
• Issued: 06/08/1976
• Est. Priority Date: 09/07/1973
• Status: Expired due to Term

• Current Assignee: Kontron Inc (Roche Holding AG)
• Original Assignee: Hoffmann-La Roche Incorporated (Roche Holding AG)
• Inventors: Guenin, Albert, Ernst, Heini
• Primary Examiner(s): Michell, Robert W.
• Assistant Examiner(s): Recla, Henry J.
• Application Number:
  US05/502,846
• Time in Patent Office: 644 Days
• Field of Search: 128/145.8, 128/145.5, 128/145.6, 128/142, 128/142.2, 128/142.3, 128/188, 128/145 R
• US Class Current: 128/204.21
• CPC Class Codes: A61M 16/0009 with sub-atmospheric pressure, e.g. during expiration
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/204 used for inhalation control
• CPC Class Codes: A61M 16/205 used for exhalation control
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit

Abstract

Regulation of the flow and pressure of the respiration gas in a respirator coupled to a patient is disclosed in regard to a respirator arrangement having a flow and pressure measuring device arranged proximate the patient connection for determining the flow and pressure of the respiration gas and converting the magnitudes, measured into electrical signals and also valve means arranged between the respiration gas source and the measuring device for controlling the flow and pressure of the respiration gas. Means are provided for obtaining a control signal for modulating the valve means by comparing the actual values measured for the flow and pressure with nominal values which themselves are calculated from preselected fixed values and said actual values.

Claims

1. Regulation of the flow and pressure of the respiration gas in a respirator during the respiration cycle in which the actual flow and pressure of the respiration gas are measured via a measuring device arranged proximate the patient connection and the measured values thereof are converted into electrical signals and in which the flow and pressure of the respiration gas are controlled during the inspiration and expiration portions of the respiration cycle via valve means arranged between the respiration gas source and the measuring device, comprising:

measuring the actual flow of respiration gas proximate the patient;

measuring the actual pressure of respiration gas proximate the patient,

calculating nominal values of flow and pressure from preselected fixed values and said actual values;

comparing the actual values measured for the flow and pressure with said nominal values; and

obtaining from said comparison a control signal for modulating the valve means and thereby regulating the flow and pressure of the respiration gas wherein the inspiration portion of the respiration cycle is comprised of two phases, and wherein said regulation includes pressure-regulating the first of said two phases and flow-regulating the second of said two phases.

2. Regulation according to claim 1 including effecting changeover from said first to said second inspiration phase at the point in which the difference between the inspiratory nominal volume and the instantaneous volume is equal to the volume which is calculated from the instantaneous flow and a flow decreasing to 0 from that point to the end of the inspiration phase.

3. Regulation according to claim 2 including comparing the inspiratory nominal volume with a value of the expired volume averaged over a predetermined number x of respiration cycles and correcting the nominal volume correspondingly for x subsequent respiration cycles.

4. Regulation according to claim 3 including triggering alarm means upon a difference occurring between the inspiratory nominal volume per respiration cycle and the average value lying above a pre-established limiting value.

5. Regulation according to claim 4 including producing when the difference between the nominal volume per respiration cycle and the average value and the difference between the final inspiratory actual volume and the nominal volume each simultaneously exceed a predetermined limiting value.

6. Regulation according to claim 2 including directing the flow of respiration gas from the instantaneous value at the changeover points to 0 according to a predetermined function.

7. Regulation according to claim 6 wherein said predetermined function is a straight line.

8. Regulation according to claim 2 including measuring the instantaneously inspired volume continuously from the flow measured.

9. Regulation according to claim 1 including altering the regulator, with a flow measured having the sign of expiration during the inspiratory portion of the respiration cycle or vice-versa and a gradient lying above a predetermined limiting value which characterize a cough criterion, to provide a fixed final expiratory pressure.

10. Regulation according to claim 9 wherein upon the occurrence of a flow characterizing the cough criterion during an inspiration, a new inspiration is begun following a pause of predetermined duration, and wherein upon the occurrence of a flow characterizing the cough criterion during an expiration, the final expiratory pressure is interposed and the end of the respiration cycle awaited.

11. Regulation according to claim 1 wherein upon a reversal of the flow direction of a predetermined amplitude and duration during the expiration time, the inspiration portion of the subsequent respiration cycle is immediately interposed.

12. Regulation according to claim 11 wherein the time difference between the preestablished cycle duration provided and the cycle duration shortened by respiration control effected by the patient is stored and summed over a plurality of respiration cycles.

13. Regulation according to claim 12 wherein the summed time reserve can be utilized in later respiration cycles in the sense of a cycle extension.

14. Regulation according to claim 1 wherein the pressure course during the first phase of inspiration follows a curve which proceeds from the measured final expiratory pressure of the preceding respiration cycle and has an externally selected gradient.

15. Regulation according to claim 14 including providing the pressure course curve with a delayed insert.

16. Regulation according to claim 14 including starting the pressure-course curve without a delay in the case of a respiration control being provided by the patient.

17. Regulation according to claim 1 wherein the pressure-course during expiration is comprised of two phases.

18. Regulation according to claim 17 wherein the pressure-course in the first phase of expiration decreases linearly to a preestablished pressure with a predetermined gradient.

19. Regulation according to claim 18 wherein the pressure-course in the second phase of expiration proceeds from the specified pressure and ends at a preestablished fixed final expiratory pressure.

20. Regulation according to claim 19 wherein in an assisted respiration mode of operation, no pressure lying below the value of the final expiratory pressure is allowed.

21. Regulation according to claim 17 wherein a fixed limiting value is preestablished for the temporal ratio of the two phases.

22. Regulation according to claim 1 wherein the final inspiratory pressure is measured and displayed.

23. Regulation according to claim 1 wherein the expired minute volume is calculated and displayed.

24. Regulation according to claim 1 wherein the temporal ratio of pressure to volume control during inspiration is displayed.