Fourier transform NMR spectroscopy employing a phase modulated rf carrier
First Claim
1. In a magnetic resonance spectrometer:
- means for generating a band of radio frequency energy for irradiation of a sample of matter to be analyzed, such band of energy having a sufficient bandwidth to cover the spectral lines of the sample to be analyzed for simultaneously exciting radio frequency magnetic resonance of different resonance spectral lines, if any, within the sample;
means for detecting the excited resonance of the sample to obtain a composite resonance signal therefrom for analysis of the sample;
means for repetitively time scanning, sampling and storing a multiplicity of successive time displaced components of the composite resonance signal in a multiplicity of respective channels;
means for reading out the signal components stored in such channels; and
said means for generating the band of radio frequency energy for irradiation of the sample including, means for generating a radio frequency carrier signal, and means for periodically shifting the phase of said carrier signal from one phase to another of at least three different relative phases in accordance with a predetermined sequence.
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Abstract
A nuclear magnetic resonance Fourier transform spectrometer includes a pulse modulated rf transmitter for delivering a train of radio frequency pulses having a pulse width pulse repetition rate to generate Fourier side bands to cover the spectral lines of the sample to be analyzed for exciting resonance of different resonance lines, if any, within the sample. Resonance of the sample is scanned in between successive transmitted pulses to obtain a multiplicity of successive time displaced components which are sampled and stored in a multiplicity of memory channels of a computer for time averaging thereof. The time averaged signal components are periodically read out and Fourier transformed to obtain a time averaged spectrum of the sample under analysis. Anomalous phase and intensity effects in the detected spectral lines are avoided by periodically shifting the phase of the pulse modulated carrier signal from one phase to another of at least three different relative phases in accordance with a predetermined sequence.
31 Citations
16 Claims
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1. In a magnetic resonance spectrometer:
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means for generating a band of radio frequency energy for irradiation of a sample of matter to be analyzed, such band of energy having a sufficient bandwidth to cover the spectral lines of the sample to be analyzed for simultaneously exciting radio frequency magnetic resonance of different resonance spectral lines, if any, within the sample; means for detecting the excited resonance of the sample to obtain a composite resonance signal therefrom for analysis of the sample; means for repetitively time scanning, sampling and storing a multiplicity of successive time displaced components of the composite resonance signal in a multiplicity of respective channels; means for reading out the signal components stored in such channels; and said means for generating the band of radio frequency energy for irradiation of the sample including, means for generating a radio frequency carrier signal, and means for periodically shifting the phase of said carrier signal from one phase to another of at least three different relative phases in accordance with a predetermined sequence. - View Dependent Claims (2, 3, 4, 5)
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6. A nuclear magnetic resonance spectrometer for producing nuclear magnetic resonance spectrum from a sample under analysis comprising means for producing a unidirectional polarizing magnetic field enveloping said sample, means for applying a plurality of time-spaced pulses of driving radio frequency magnetic field to said sample for an experiment time T to produce a series of successive free precession signals from said sample responsive to said driving pulses, means for demodulating said free precession signals to obtain a series of free induction decay envelope signals, means for time-averaging discrete segments of said decay signals over the series of successive signals, wherein said means for applying a plurality of time-spaced pulses of driving radio frequency magnetic field includes means for providing said pulses in Ni different phases relative to a reference phase where i is an integer greater than 2, means for dividing said experiment time T into i approximately equal time increments and means for arranging said time-spaced pulses in i different sets.
- View Dependent Claims (7, 8, 9)
- 9. The spectrometer of claim 8 wherein i equals 4, such that
- space="preserve" listing-type="tabular">SET 1 equals N.sub.1, N.sub.2, N.sub.3, N.sub.4, N.sub.1, N.sub.2, N.sub.3, N.sub.4 ... SET 2 equals N.sub.1, N.sub.3, N.sub.1, N.sub.3, N.sub.1, N.sub.3, N.sub.1, N.sub.3 ... SET 3 equals N.sub.1, N.sub.4, N.sub.3, N.sub.2, N.sub.1, N.sub.4, N.sub.3, N.sub.2 ... SET 4 equals N.sub.1, N.sub.1, N.sub.1, N.sub.1, N.sub.1, N.sub.1, N.sub.1, N.sub.1 ...
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10. In a method for obtaining magnetic resonance of a sample under analysis including the steps of:
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generating a band of radio frequency energy; irradiating a sample of matter to be analyzed with the band of radio frequency energy, such energy having a sufficient bandwidth to cover the spectral lines of the sample to be analyzed for simultaneously exciting radio frequency magnetic resonance of different resonance spectral lines, if any, within the sample; detecting the excited resonance of the sample to obtain a composite resonance signal therefrom for analysis of the sample; repetitively time scanning, sampling and storing a multiplicity of successive time displaced components of the composite resonance signal in a multiplicity of respective channels; reading out the signal components stored in such channels; and wherein the step of generating the band of radio frequency energy for irradiation of the sample includes the step of, generating a radio frequency carrier signal, and shifting the phase of the carrier signal from one phase to another of at least three different relative phases in accordance with a predetermined sequence. - View Dependent Claims (11, 12)
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13. The method of obtaining magnetic resonance spectrum of a sample under analysis including the steps of:
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producing a unidirectional polarizing magnetic field enveloping said sample, applying a plurality of time-spaced impulses of driving radio frequency magnetic field to said sample for an experiment time T to produce a series of successive free precession signals from said sample responsive to said driving pulses, demodulating said free precession signals to obtain a series of free induction decay envelope signals, time-averaging discrete segments of said decay signals over the series of successive signals, wherein said step of applying said plurality of time-spaced pulses includes providing said pulses in Ni different phases relative to a reference where i is an integer greater than 2, dividing said experiment time T into i equal time increments and arranging said time-spaced pulses in i different sets. - View Dependent Claims (14, 15, 16)
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16. The method of claim 14 wherein i = 4.
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Specification