Negative pressure control system

• US 3,976,574 A
• Filed: 11/04/1974
• Issued: 08/24/1976
• Est. Priority Date: 11/04/1974
• Status: Expired due to Term

• Current Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Original Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Inventors: White, Robert Lee
• Primary Examiner(s): Granger, Theodore A.
• Application Number:
  US05/520,336
• Time in Patent Office: 659 Days
• Field of Search: 210/90, 210/22, 210/23, 210/321, 210/85, 210/87, 210/433, 210/96, 210/188
• US Class Current: 210/188
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3337 Controlling, regulating pressure or flow by means of a valve by-passing a pump
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 61/32 Controlling or regulating
• CPC Class Codes: Y10S 210/929 Hemoultrafiltrate volume measurement or control processes

Abstract

A dialysate flow control system is disclosed for an artificial kidney machine. The flow control system produces dialysate flow at negative pressure through the dialyzer and comprises a flow controller and first pump upstream of the dialyzer and a second pump downstream of the dialyzer. The negative pressure between the flow regulator and the first pump is utilized for deaeration and an air accumulator is disposed downstream of the first pump and provided with an air discharge path into the dialysate flow path downstream of the dialyzer. A negative pressure regulator automatically regulates the dialysate pressure in the dialyzer at a manually adjustable value and comprises regulator means responsive to the average value of negative pressure in the dialyzer to provide suction relief to the second pump as needed to maintain the selected pressure value.

Claims

1. In a dialysis machine, a negative pressure control system comprising a liquid conduit defining a flow path extending from a liquid source to a liquid drain, and adapted to include a dialyzer in said flow path, a flow controller in said flow path upstream of the dialyzer and constructed and arranged to restrict the flow rate through said conduit to a predetermined maximum value, a first positive displacement pump in said flow path between the flow controller and the dialyzer and having a pumping capacity exceeding said maximum value whereby a negative pressure is produced in the conduit between the flow controller and the first pump, a second positive displacement pump in said flow path between the dialyzer and the drain and having a pumping capacity exceeding that of said first pump whereby a negative pressure is produced in the conduit between the pumps and in the dialyzer, deaerating means in said flow path including a gas accumulator upstream of said dialyzer and a gas discharge conduit connected between the gas accumulator and the flow path downstream of said dialyzer, and negative pressure control means connected with the conduit between the pumps for regulating the negative pressure of the liquid in the dialyzer.

2. The invention as defined in claim 1 including regulating means having a control input adapted to be connected to the dialyzer and having a controlled output adapted to be connected between a source of fluid and said conduit downstream of said dialyzer, said regulating means being adapted to admit fluid to said conduit when the pressure in said dialyzer decreases below a predetermined value and thereby regulate the negative pressure at said dialyzer to said predetermined value.

3. The invention as defined in claim 2 including a mixer in said flow path upstream of said dialyzer and downstream of said flow restricting means, said mixer being connected with a source of concentrated dialysate solution, a second gas accumulator in said flow path between said flow restricting means and said mixer, and a concentration monitor device downstream of said second gas accumulator.

4. In a dialysis machine, a dialysate pressure control system comprising, a liquid conduit defining a flow path extending from a liquid source to a liquid drain and adapted to include a dialyzer in said flow path, flow producing means in said flow path for producing a negative pressure in the dialyzer, and regulating means including a valve member and a pressure actuated member, said pressure actuated member being in fluid communication with the inlet and the outlet of the dialyzer whereby the negative pressure upstream and downstream of the dialyzer is averaged and actuates the valve member between open and closed positions, conduit means for a source of regulating fluid, one side of the valve member being in fluid communication with the conduit means and the other side being in fluid communication with said conduit downstream of the dialyzer, said regulating means being constructed and arranged to admit regulating fluid to said conduit downstream of the dialyzer when the pressure in said dialyzer decreases below a predetermined value and thereby regulate the negative pressure at said dialyzer to said predetermined value.

5. The invention as defined in claim 4 wherein said regulating means further comprises pressure drop averaging means having an output connected with said pressure actuated member and having an input adapted to be connected with said dialyzer whereby said regulator is operative to regulate the average dynamic negative pressure in the dialyzer.

6. The invention as defined in claim 5 wherein said pressure averaging means comprises a conduit connected in parallel relation with said dialyzer and having a port at the midpoint thereof connected with said pressure actuated member.

7. The invention as defined in claim 5 including a flow rate meter having an inlet and an outlet, the meter inlet connected with the outlet of said dialyzer, valve means in said flow path for closing said flow path upstream of said dialyzer and downstream of said dialyzer whereby the regulated negative pressure is maintained in said dialyzer, said valve means including an auxiliary flow path for said liquid which bypasses said dialyzer, a connection between the meter outlet and said auxiliary flow path.

8. The invention as defined in claim 7 wherein said negative pressure producing means comprises a first pump downstream of said dialyzer, a flow restricting means in said flow path upstream of said dialyzer and a second pump in said flow path between said flow restricting means and said dialyzer.

9. The invention as defined in claim 8 wherein the fluid outlet of said regulating means is connected to said flow path between said dialyzer and said first pump.

10. The invention as defined in claim 9 including a gas accumulator upstream of said dialyzer and a gas discharge conduit connected between the gas accumulator and said flow path downstream of said dialyzer.