Asthma treatment by inhalation of micronized N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate

• US 3,985,868 A
• Filed: 01/13/1975
• Issued: 10/12/1976
• Est. Priority Date: 06/27/1973
• Status: Expired due to Term

• Current Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Original Assignee: American Colloid Company (Minerals Technologies Incorporated)
• Inventors: Corey, Howard Seebree Jr., Barringer, William Charles, Hansen, Lloyd Frank
• Primary Examiner(s): Schenkman, Leonard
• Application Number:
  US05/540,735
• Time in Patent Office: 638 Days
• Field of Search: 424/250, 424/45, 424/46
• US Class Current: 424/45
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: C07D 295/215 Radicals derived from nitrogen analogues of carbonic acid

Abstract

Asthma is effectively treated by inhalation of powder dispensed from an aerosol suspension of powdered N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate, which is dispersed as a fine powder, essentially below 10 microns in particle size, which gives an improved ratio of absorption in the lungs as compared to systemic absorption.

Claims

1. A pressurized dispenser for the treatment of asthma containing a suspension consisting essentially of an effective amount of N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate having a particle size range of 0.5 microns to 10 microns, about 5% by weight of ethanol and a propelling amount of a low boiling chlorofluoalkane in a container having a metering valve.

2. The dispenser of claim 1 in which the propellant is dichlorofluoromethane and the container is stainless steel.

3. The dispenser of claim 1 in which the propellant is dichlorofluoromethane and the container is aluminum.