Automatic gamma radiation scanning device and feed mechanism for plural sample holders

• US 3,986,028 A
• Filed: 01/20/1975
• Issued: 10/12/1976
• Est. Priority Date: 01/20/1975
• Status: Expired due to Term

• Current Assignee: Salk Institute for Biological Studies
• Original Assignee: Salk Institute for Biological Studies
• Inventors: Byrd, William J.
• Primary Examiner(s): Smith, Alfred E.
• Assistant Examiner(s): Moore, David K.
• Application Number:
  US05/542,118
• Time in Patent Office: 631 Days
• Field of Search: 250/363, 250/328, 250/337, 250/364
• US Class Current: 250/328
• CPC Class Codes: G01T 7/08 Means for conveying samples received

Abstract

Apparatus is disclosed for measuring the level of gamma radiation contained in a plurality of biological samples which are located on the fibrous sheet member carried by a sample holder. The apparatus is adapted to count the radiation level of the number of closely spaced samples located in rows and columns on the sheet by automatically sequencing through the individual samples within the rows and to advance the holder to bring successive rows into proximity with the detector. The detector is moved from sample to sample within the rows, although a number of detectors can be employed. A plurality of sample holders are automatically advanced to the detector.

Claims

1. Apparatus for measuring the gamma radiation label in each of a plurality of samples located in a number of rows on a sheet member carried by a sample holder, comprising:

a measuring station having at least one gamma radiation detector adapted for movement along a first path;

means for moving said detector along said first path from sample location to sample location within a row of samples to thereby measure the gamma radiation label of each of said samples along said first path;

means for holding a plurality of said sample holders; and

,

means for sequentially advancing said sample holders from said holding means to said measuring station to bring successive rows in line with said first path for measuring the gamma radiation label of said samples and for thereafter moving said sample holder away from said measuring station, said sequential advancing means comprising an endless flexible link means movable around a closed loop, the upper reach of which is generally horizontal and defines a second path, the endless belt having a series of spaced apart transverse projections adapted to engage a single sample holder and move the same toward said measuring station as said belt moves around said loop and means for driving said endless belt around said loop.

2. Apparatus as defined in claim 1 wherein each of said sample holders comprises a generally flat rectangular support member and a cover, said sheet member being located between said support member and cover and comprising a thin fibrous sheet adapted to absorb a measured amount of sample solution containing a radioactive label at predetermined locations spaced apart from one another and located in successive rows, said cover having a plurality of fenestrations exposing said plurality of sample locations of said fibrous sheet.

3. Apparatus as defined in claim 2 wherein said cover and support member have respective cooperating tongue and groove portions for resiliently holding said cover to said support member.

4. Apparatus as defined in claim 3 wherein said cover has opposed downwardly directed sidewalls with facing tongue portions, each of which are adapted to engage aa groove located in the adjacent sidewall of said support member.

5. Apparatus as defined in claim 2 wherein said cover includes a linear array of said fenestrations generally arranged in rows and columns.

6. Apparatus as defined in claim 5 wherein said cover has eight rows of fenestrations and each row has 12 fenestrations.

7. Apparatus as defined in claim 2 wherein said cover is fabricated from an aluminum alloy.

8. Apparatus as defined in claim 1 wherein said sequential advancing means is adapted to move said sample holder an incremental distance so as to bring a subsequent row of samples into proximity with aid detector.

9. Apparatus as defined in claim 1 wherein said detector moving means comprises a guide means holding said detector a predetermined distance from said sample holder and slideable along said first path, link means connecting said detector to a controllable drive means to move said detector a predetermined distance along said first path, said predetermined distance being equal to the spacing between sample locations.

10. Apparatus as defined in claim 9 wherein said link means comprises a pair of laterally spaced ball chains, each of which is connected to said detector.

11. Apparatus as defined in claim 9 wherein said driving means comprises a step motor adapted to move said chain means a predetermined distance in response to being activated.

12. Apparatus as defined in claim 1 wherein said plurality of samples are located in a rectilinear array having rows and columns with the rows being generally parallel to said first path so that movement of said detector along said first path brings said detector into proximity with each of said samples in said row to measure the gamma radiation label thereof.

13. Apparatus as defined in claim 1 wherein said driving means comprises a step motor operably connected to said endless flexible link means.

14. Apparatus as defined in claim 1 wherein the spacing between said transverse projections exceeds the dimension of said sample holders so that each of said projections engages a sample holder from said holding means and advances the same toward said measuring station in response to movement of the upper reach of said endless link means along said second path.

15. Apparatus as defined in claim 1 wherein each of said transverse projections comprise laterally spaced apart pins adapted to contact a sample holder near opposite ends thereof and move the same toward said measuring station.

16. Apparatus as defined in claim 1 wherein said holding means comprises a guide means for stacking said plurality of sample holders on one another, said guide means permitting a single sample holder to be initially advanced from said holding means toward said measuring station.

17. Apparatus for holding a plurality of samples located in a rectilinear array for use in gamma radiation counting apparatus and comprising:

a generally flat support member having a generally rectangular surface area;

a thin fibrous absorbent sheet member overlying said surface area and containing a plurality of sample locations in a plurality of rows and columns spaced apart from one another;

a shielding cover overlying said fibrous sheet and being resiliently coupled to said support member, said cover having a plurality of fenestrations generally coinciding with said sample locations, said cover being adapted to isolate one sample location from an adjacent sample location during gamma radiation counting and to maintain said fibrous sheet in predetermined and uniform spacial relation relative to the counting apparatus.

18. Apparatus as defined in claim 17 wherein said cover has downwardly depending side members with inwardly protruding tongue portions and said support member has cooperating recesses adapted to receive said tongue members in fitting engagement.

19. Apparatus as defined in claim 18 wherein said support member is fabricated of a plastic-like material and has a thickness generally coextensive with the length of said downwardly depending side members and containing said recesses.

20. Apparatus as defined in claim 17 wherein the spacing between adjacent rows of samples is a uniform predetermined distance and the distance from the row adjacent each edge thereof is approximately one half of said predetermined distance so that two of said samples arranged in close edge relation would also have the rows of each apparatus adjacent the edges spaced said uniform predetermined distance from one another.

21. Apparatus as defined in claim 17 wherein eight rows, each row having 12 samples are arranged thereon in said rectilinear array.

22. Apparatus as defined in claim 17 wherein the outside dimensions are about 5 inches by 8 inches and the fenestrations are about 3/8 inch diameter openings spaced on about 5/8 inch centers.

23. Apparatus as defined in claim 17 wherein said cover is fabricated from aluminum.

24. Apparatus for measuring the gamma radiation label in each of a plurality of samples located in a number of rows on a sheet member carried by a sample holder, comprising:

a measuring station station having at least one gamma radiation detector adapted for movement along a first path;

means for moving said detector along said first path from sample location to sample location within a row of samples to thereby measure the gamma radiation label of each of said samples along said first path;

means for holding a plurality of said sample holders;

means for sequentially advancing said sample holders from said holding means to said measuring station to bring successive rows in line with said first path for measuring the gamma radiation label of said samples and for thereafter moving said sample holder away from said measuring station; and

,

each of said sample holders comprising a generally flat rectangular support member and a cover, said sheet member being located between said support member and cover and comprising a thin fibrous sheet adapted to absorb a measured amount of sample solution containing a radioactive label at predetermined locations spaced apart from one another and located in successive rows, said cover having a plurality of fenestrations exposing said plurality of sample locations of said fibrous sheet.

25. Apparatus as defined in claim 24 wherein said sequential advancing means comprises an endless flexible link means movable around a closed loop, the upper reach of which is generally horizontal and defined a second path, the endless belt having a series of spaced apart transverse projections adapted to engage a single sample holder and move the same toward said measuring station as said belt moves around said loop and means for driving said endless belt around said loop.