Medical-analytical gas detector

• US 3,987,303 A
• Filed: 02/06/1975
• Issued: 10/19/1976
• Est. Priority Date: 02/06/1975
• Status: Expired due to Term

• Current Assignee: Hewlett-Packard Company (HP Inc.)
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Wong, Jacob Y., Bridgham, John A., Hill, Charles M., Willis, Barry G., Stoft, Paul E., Fostick, Moshe A., Lazier, John K. D., Chaney, Robert L.
• Primary Examiner(s): Smith, Alfred E.
• Assistant Examiner(s): Grigsby, T. N.
• Application Number:
  US05/547,670
• Time in Patent Office: 621 Days
• Field of Search: 250/343, 250/351, 250/510, 250/373, 250/573, 356/51
• US Class Current: 250/343
• CPC Class Codes: G01N 21/3504 for analysing gases, e.g. multi-gas analysis
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

A gas analyzer is provided which is particularly suited for making transcutaneous measurement of the CO₂ concentration in the blood.

In accordance with one embodiment of the invention, sample gases from the body are circulated in a cavity of the device. A rotating wheel in the cavity includes two reference cells and a sample cell which are sequentially rotated into the optical path between a source and a detector. Three signals are thereby provided which may be combined to give an output indication of the CO₂ concentration in the body fluids. In a preferred embodiment, the sample cell is an "inverted cell" being in open communication with the sample gas circulating in the device so that the gas in the sample cell is a portion of the circulating gas which also surrounds the two reference cells. An output indication is thereby obtained which is insensitive to contaminants in the sample.

In accordance with another embodiment, the sample cell is isolated from the region surrounding the wheel and positioned so as to be presented in series with the reference cells in the optical detection path.

In preferred embodiments, the rotating wheel contains a number of permanent magnets which interact with a number of electromagnets driven in sequence to provide rotation of the wheel.

Claims

1. A device for detecting a component gas in a sample gas comprising:

a housing;

source means mounted within the housing for providing radiation in a preselected spectral band having at least one absorption line of the component gas to be detected;

detector means mounted in the housing for detecting radiation in the preselected spectral band;

a plurality of reference cells, each reference cell containing a reference gas including a standard amount of said component gas to be detected;

a sample cell for containing a quantity of sample gas including the component gas to be detected; and

sequencer means in the housing for introducing in time sequence each of the reference cells and also the sample cell into an optical path between the source means and the detector means;

said detector means being responsive to radiation incident thereon when each of the reference cells is in the optical path and when the sample cell is in the optical path, for producing thereby a plurality of detector output signals whose amplitudes are dependent on the amount of the component gas which may be present in the plurality of reference cells and the sample cell respectively said plurality of signals being operable in predetermined formulation to provide an indication of the concentration of the component gas in the sample gas.

2. A device as in claim 1 wherein:

the plurality of reference cells comprises a first reference cell for containing a first reference gas including a first standard amount of said component gas to be detected, and a second reference cell for containing a second reference gas including a second standard amount of the component gas to be detected; and

said detector means is responsive to radiation incident thereon when each of the three cells is in the optical path, for producing thereby three detector output signals whose amplitudes are dependent on the amount of the component gas which may be present in the first reference cell, the second reference cell, and the sample cell respectively, said three signals being operable in predetermined formulation to provide an indication of the concentration of the component gas in the sample gas.

3. A device as in claim 2 wherein:

the housing has a cavity for circulating therein a volume of the sample gas; and

the sample cell comprises a cell in open communication with the cavity for containing a quantity of sample gas which is a portion of the volume of sample gas circulating within the cavity.

4. A device as in claim 3 wherein the sequencer means comprises a rotating wheel in which the first and second reference cells and the sample cell are positioned.

5. A device as in claim 4 further comprising:

a plurality of permanent magnets embedded in the rotating wheel; and

a plurality of electromagnets included within the housing for activation in a predetermined sequence to attract and repel the permanent magnets embedded in the wheel, thereby inducing rotation of the wheel.

6. A device as in claim 5 further comprising:

a plurality of timing marks spaced around the periphery of the rotating wheel; and

electro-optical means for reflecting optical signals from the timing marks to generate electrical signals for controlling the speed of the rotating wheel.

7. A device as in claim 6 further comprising:

temperature sensing means for detecting the temperature of the gas in the sample cell; and

temperature control means responsive to the temperature sensing means for maintaining the temperature of the gas in the sample cell at a desired temperature.

8. A device for use in measuring the concentration of a component gas in the fluids of a human body, said device comprising:

a housing;

source means mounted with the housing for providing radiation in a preselected spectral band having at least one absorption line of the component gas to be detected;

detector means mounted in the housing for detecting radiation in the preselected spectral band;

a plurality of reference cells, each reference cell containing a reference gas including a standard amount of said component gas to be detected;

a sample cell for containing a quantity of sample gas including the component gas to be detected;

sequencer means in the housing for sequentially introducing the reference cells and the sample cell into an optical path between the source means and the detector means; and

a screening member mounted in a recessed chamber in communication with the sample cell for maintaining a stable geometry of an interface between the recessed chamber and a region of the skin surface of the body when the device is brought into intimate contact with said region;

said detector means being responsive to radiation incident thereon when each of the reference cells and the sample cell is in the optical path, for producing thereby a plurality of detector output signals whose amplitudes are dependent on the amount of the component gas which may be present in the plurality of reference cells and the sample cell respectively, said plurality of signals being operable in predetermined formulation to provide an indication of the concentration of the component gas in the sample gas.

9. A device as in claim 8 further comprising:

a membrane stretched across the recessed chamber for allowing gases from the human body to enter the cavity in the housing while preventing the passage of body fluids thereinto.

10. A device as in claim 8 further comprising:

an adhesive on a portion of the housing in contact with the skin to provide a sealed region between the sample cell and the body.

11. A device as in claim 8 for use in measuring the concentration of said component gas in the fluids of a human body, wherein:

the sequencer means comprises a wheel operable for introducing in time sequence each of the reference cells and also the sample cell into the optical path between the source means and the detector means; and

the detector means is responsive to radiation incident thereon when each of the reference cells is in the optical path and when the sample cell is in the optical path for producing thereby a plurality of detector output signals whose amplitudes are dependent on the amount of the component gas which may be present in the plurality of reference cells and the sample cell respectively, said plurality of signals being operable in predetermined formulation to provide an indication of the concentration of the component gas in the sample gas.

12. A device as in claim 11 wherein:

the housing has a cavity for circulating therein a volume of the sample gas; and

the sample cell comprises a cell in open communication with the cavity for containing a quantity of sample gas which is a portion of the volume of sample gas circulating within the cavity.

13. A device as in claim 12 further comprising:

a plurality of permanent magnets embedded in the rotating wheel; and

a plurality of electromagnets included within the housing for activation in a predetermined sequence to attract and repel the permanent magnets embedded in the wheel, thereby inducing rotation of the wheel.

14. A device as in claim 13 further comprising:

a plurality of timing marks spaced around the periphery of the rotating wheel; and

electro-optical means for reflecting optical signals from the timing marks to generate electrical signals for controlling the speed of the rotating wheel.

15. A device as in claim 14 further comprising:

temperature sensing means for detecting the temperature of the gas in the sample cell; and

temperature control means responsive to the temperature sensing means for maintaining the temperature of the gas in the sample cell at a desired temperature.

16. A device as in claim 8 for use in measuring the concentration of said component gas in the fluids of the human body, wherein:

the sequencer means comprises a rotating wheel operable for introducing in time sequence said plurality of reference cells into said optical path;

the sample cell is positioned adjacent said wheel for operation in series with each reference cell in the optical path between the source and the detector; and

the detector means is responsive to radiation incident thereon when each of the reference cells is in series with the sample cell in the optical path for producing thereby a plurality of detector output signals whose amplitudes are dependent on the amount of the component gas which may be present in the plurality of reference cells and the sample cell respectively, said plurality of signals being operable in predetermined formulation to provide an indication of the concentration of the component gas in the sample gas.

17. A device as in claim 16 further comprising:

a membrane stretched across the recessed chamber for allowing gases from the human body to enter the cavity in the housing while presenting the passage of body fluids thereinto.

18. A device as in claim 17 further comprising:

an adhesive on a portion of the housing in contact with the skin to provide a sealed region between the sample cell and the body.

19. A device as in claim 16 further comprising:

a plurality of permanent magnets embedded in the rotating wheel; and

a plurality of electromagnets included within the housing for activation in a predetermined sequence to attract and repel the permanent magnets embedded in the wheel, thereby inducing rotation of the wheel.

20. A device as in claim 17 further comprising:

a plurality of timing marks spaced around the periphery of the rotating wheel; and

electro-optical means for reflecting optical signals from the timing marks to generate electrical signals for controlling the speed of the rotating wheel.

21. A device as in claim 18 further comprising:

temperature sensing means for detecting the temperature of the gas in the sample cell; and

temperature control means responsive to the temperature sensing means for maintaining the temperature of the gas in the sample cell at a desired temperature.