Antimicrobial sutures
First Claim
1. A surgical aid having long-lasting, leach resistant antimicrobial properties the surface of which is coated with an ionic block elastomer of the formula:
- ##EQU1## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Z and Y are selected from hydroxyl and isocyanate groups, ZY is the urethane residue of the condensation of Z and Y;
n is an integer from 10 to 1,000;
B- is an anionic polymer and X is an anionic or cationic antimicrobial compound.
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Abstract
A surgical suture is coated with an ionically bonded block elastomeric copolymer of a polyquaternary polyurethane and a polyanionic polymer such as heparin. The coated suture is receptive to treatment with antimicrobial compounds to produce a suture having long-lasting antimicrobial properties which inhibit bacterial growth in and immediately around the suture. The coated suture is also receptive to dyes for the preparation of colored sutures. Surgical aids other than sutures such as films, fabrics, wound dressings and the like may be coated and rendered antimicrobial or colored in a like manner.
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Citations
29 Claims
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1. A surgical aid having long-lasting, leach resistant antimicrobial properties the surface of which is coated with an ionic block elastomer of the formula:
- ##EQU1## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Z and Y are selected from hydroxyl and isocyanate groups, ZY is the urethane residue of the condensation of Z and Y;
n is an integer from 10 to 1,000;
B- is an anionic polymer and X is an anionic or cationic antimicrobial compound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- ##EQU1## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
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10. A colored surgical aid, the surface of which is coated with an ionic block elastomer of the formula:
- ##STR8## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, and R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Z and Y are selected from hydroxyl and isocyanate groups, ZY is the urethane residue of the condensation of Z and Y;
n is an integer from 10 to 1,000;
B- is an anionic polymer and X is an anionic or cationic dye group. - View Dependent Claims (11, 12, 13, 14, 15)
- ##STR8## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, and R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
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16. A sterile surgical suture, the surface of which is coated with an ionic block elastomer of the formula:
- ##STR9## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Z and Y are selected from hydroxyl and isocyanate groups, ZY is the urethane residue of the condensation of Z and Y;
n is an integer from 10 to 1,000; and
B- is an anionic polymer. - View Dependent Claims (17, 18)
- ##STR9## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
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19. A method of preparing an antimicrobial surgical aid comprising the steps of contacting the surface of a surgical aid with a solution of an ionic block elastomer of the formula:
- ##STR10## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Z and Y are selected from hydroxyl and isocyanate groups, ZY is the urethane residue of the condensation of Z and Y, n is an integer from 10 to 1,000 and B- is an anionic polymer, drying said surgical aid to leave a residual coating of said ionic block elastomer thereon, and thereafter contacting said coated surgical aid with an anionic or cationic antimicrobial compound. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- ##STR10## wherein R is C1 -15 alkylene, R2 is lower alkylene, R3, R4 and R5 are selected from hydrogen and lower alkyl, R1 is a liquid prepolymer having a molecular weight from 1,000 to 3,000 selected from the class consisting of polyether, silicone, polyurethane, and polyamide;
Specification