Portable cardiac monitoring system and method

• US 3,991,747 A
• Filed: 08/05/1974
• Issued: 11/16/1976
• Est. Priority Date: 06/23/1972
• Status: Expired due to Term

• Current Assignee: Albert L. Stanly
• Original Assignee: Albert L. Stanly
• Inventors: Stanly, Albert L., Wimmer, Gunther W.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US05/495,091
• Time in Patent Office: 834 Days
• Field of Search: 128/206 A, 128/206 B, 128/206 C, 128/206 E, 128/206 G, 128/206 R, 128/206 V, 128/2.1 A, 128/419 P, 128/419 PT
• US Class Current: 600/510
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/327 Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads
• CPC Class Codes: A61B 5/332 Portable devices specially adapted therefor
• CPC Class Codes: Y10S 128/902 Biological signal amplifier

Abstract

A plurality of electrodes affixed at selected positions of the chest of an ambulatory patient sense potentials due to cardiac or pacemaker action of the patient, for transmission by radio, telephone or other means to an EKG and pacemaker performance measuring and analyzing facility. The electrodes are connected to timing, control and signal processing means contained in a smal, conveniently worn or stored housing. Signals from sequenced, selected combinations of electrodes are serially transmitted for given intervals after modification, and in the case of telephone transmission are converted to audio output. The pairs of electrodes are arrayed to yield substantially all the data, from as few as four electrodes connected to provide bipolar leads, obtainable from the conventional 12 lead EKG. The signal processing system includes highly sensitive stable circuit elements providing low current, very high impedance operation and minimizing variations and limitations imposed by electrode attachment, as well as minimizing local variation in skin resistance of the patient and common mode operation with conventional electrical sources. Means are provided for processing and transmitting a power source signal as a marker and as an indication of the effectiveness and remaining useful life of the power source which may comprise an ordinary falshlight battery. Where a pacemaker is used, the transmitted signals are in a form to provide data for evaluation of the pacemaker effectiveness. At the receiving end, the transmitted signals are recorded or displayed on an EKG recorder, tape recorder, oscilloscope, or heart-pacer condition readout apparatus.

Claims

1. A system for processing electric currents due to potentials accompanying cardiac action of an ambulatory patient or electrical impulses from a pulse generator designed to pace the heart for multiplex transmission to monitoring facilities, comprising:

a plurality of electrodes adapted to electrically contact the body of a patient, amplifying means for amplifying signals fed thereto, means coupled to the amplifying means for providing an indication of information carried by amplified signals from the amplifying means, a plruality of buffer amplifier means coupled between the amplifying means and the electrodes, and sequencing means coupled to and controlling the buffer amplifier means, the sequencing means including means for rendering selected ones of the buffer amplifier means conductive to pass signals to the amplifying means and for simultaneously coupling a selected one of the buffer amplifier means as a ground connection in response to potentials from selected ones of said electrodes at selected intervals.

2. The invention as set forth in claim 1 wherein there are four said electrodes and wherein said buffer amplifier means comprises five buffer amplifiers, the first electrode being adapted to be attached to the manubrium of a patient and electrically connected to a first one of the five buffer amplifiers, a second electrode being adapted to be attached to the outer left clavicle of a patient and connected to second and third ones of the five buffer amplifiers, a third electrode being adapted to be disposed in the region of the V₅ position and connected to a fourth one of the five buffer amplifiers, and a fourth electrode being adapted to be disposed in the region of the V₁ position and connected to a fifth one of the five buffer amplifiers, and further including ground switch means coupled to the sequencing means and the buffer amplifiers to ground the fifth buffer amplifier when the first and second buffer amplifiers are conductive.

3. The invention as set forth in claim 1 further including hold means for preventing operation of the sequencing means to continue passage of signals by the buffer amplifier means to the amplifying means in response to potentials from selected ones of the electrodes.

4. The invention as set forth in claim 1 further including battery means coupled to power said system, battery test means, and oscillator means, the oscillator means being coupled to the output of said amplifying means, the battery test means being coupled to the oscillator means and to the battery means for providing a signal to the oscillator means indicating the condition of the battery means.

5. The invention as set forth in claim 4 further including override means coupled to said battery test means for overriding all other signals to said oscillator means with said battery test signal.

6. A cardiac monitoring system comprising a plurality of electrodes adapted to be coupled to the body of a patient to derive signals, a voltage controlled oscillator, timing means for gating the signals from the electrodes to the voltage controlled oscillator, the voltage controlled oscillator generating output signals representative of the signals derived from the electrodes and means responsive to the output signals for providing an indication of information carried by said output signals, a power supply for powering the system, and an arrangement for periodically generating a signal representing the relative strength of the power supply comprising threshold means, means coupled between the timing means and the threshold means for periodically actuating the threshold means, means coupling the threshold means to the power supply, the threshold means including means which is operative when actuated to provide a power supply test signal to the voltage controlled oscillator if the strength of the power supply is at least equal to a predetermined threshold level, the voltage controlled oscillator including means responsive to the power supply test signal for generating an output signal having a frequency representing the power supply test signal.

7. The invention defined in claim 6, wherein the power supply test signal comprises a pulse having an amplitude representing the strength of the power supply.

8. A system for sensing and amplifying electrical potentials generated in conjunction with cardiac activity or activity from a pulse generator designed to pace the heart for transmission to distant monitoring facilities comprising:

signal processing means, a plurality of electrodes connected to said signal processing means, the signal processing means including means for receiving and amplifying currents generated in conjunction with said potentials, control means for controlling said signal processing means, means connecting the control means to said signal processing means to activate the signal processing means at selected intervals and in selected sequences to conduct currents due to potentials sensed by combinations of the electrodes, means for providing an indication of information carried by currents amplified by said means for receiving and amplifying, power source means coupled to power the signal processing means and the control means, the power source means comprising a direct current power source and power source test means coupled to the power source for receiving a signal from the power source and for processing the power source signal to generate a power source status output signal to said signal processing means for transmission to said monitoring facilities at selected time intervals, said control means including means for activating the power source test means to generate a power source status output signal at selected times during cycles of operation of the system, and further including means for activating the power source test means to generate a power source status output signal at any time during one of the cycles of operation of the system whenever initiated by an operator.

9. A system for processing electrocardiac potentials to provide signals for transmission to facilities for recording and analyzing such signals comprising:

electrode means adapted to be affixed in a selected pattern to the body of a patient for sensing and conducting signals produced by electrocardiac potentials, electronic means coupled to the electrode means for amplifying and multiplexing said signals, the electronic means including a plurality of amplifier means, each of the amplifier means comprising a field effect transistor coupled to amplify signals from the electrode means, a plurality of gating means coupled to the electrode means for selectively coupling the electrode means to the amplifier means, each of said gating means comprising a buffer amplifier and timing means for controlling the buffer amplifier, said plurality of amplifier means providing high gain amplification of signals from the electrode means, a differential amplifier coupled to the amplifier means for generating signals representing the difference between signals amplified by the amplifier means, oscillator means coupled to generate a signal having a frequency determined by the signals representing the difference, said oscillator means comprising a voltage controlled oscillator, indicator means coupled to the oscillator means for providing an indication of information carried by the signal generated by the oscillator means and buffer means controlling application of the signals representing the difference to the oscillator means.

10. A system for receiving and transmitting cardiac signals associated with the heart action of a patient or his implanted pulse generator designed to pace the heart comprising:

a plurality of electrodes for measuring potentials associated with heart action of a patient, gain means and control means, means connecting the electrodes to the gain means, the gain means being controlled by the control means to conduct current from selected combinations of electrodes at selected intervals, the gain means including amplifier means and voltage controlled oscillator means, means connecting the voltage controlled oscillator means to the output of the amplifier means, means coupled to the voltage controlled oscillator means for providing an indication of information carried by signals from the voltage controlled oscillator means, the voltage controlled oscillator means including first and second differential amplifier means, each differential amplifier means comprising two transistors, each having a base, an emitter and a collector, means connecting the base of a first transistor of the first differential amplifier means to the output of the amplifier means, means for providing the collector of the first transistor and the base of a first transistor of said second differential amplifier means with the same potential, the base of the second transistor of the first differential amplifying means being coupled to ground, means connecting the collector of the second transistor of the first differential amplifying means to the base of the second transistor of the second differential amplifying means, means for providing the emitter reactance means, an analog switch, means connecting the collector of the first transistor of the first differential amplifying means to the reactance means and to the analog switch, a source of positive potential, means connecting said analog switch and reactance means to the source of positive potential, resistance means, means connecting the collector of the second transistor of the first differential amplifying means to the resistance means, means connecting the resistance means to the source of positive potential, means connecting the collectors of the first and second transistors of the second differential amplifying means to the source of positive potential, means connecting the emitters of the first and second transistors of the first and second differential amplifying means to a source of negative potential, a PNP transistor having a base, an emitter and a collector, means connecting the collector of the second transistor of the second differential amplifying means to the base of the PNP transistor, means connecting the emitter of the PNP transistor to the source of positive potential, the second differential amplifying means being set to provide bias current to the PNP transistor when potentials at the bases of the transistors comprising said second differential amplifying means are equal, an NPN transistor having a base, an emitter and a collector, means connecting the collector of said PNP transistor to the base of the NPN transistor, means connecting the collector of the NPN transistor to the source of positive potential, and means connecting the emitter of said NPN transistor to the emitters of the transistors comprising said first differential amplifier means to the emitters of the transistors comprising said second differential amplifying means.

11. The invention as set forth in claim 10 further including a power source, comprising battery means coupled to power said system, and battery test means for providing a signal indicating the effectiveness of the battery means, means coupling the battery test means to the battery means and to the base of the second transistor of said first differential amplifier means of said voltage controlled oscillator means.

12. The invention as set forth in claim 10 further including means coupled to the emitter of the first transistor in said second differential amplifier means for limiting the maximum frequency output of said voltage controlled oscillator means.

13. The invention as set forth in claim 12 further including first and second conduction transistors each having an emitter, a collector and a base, means connecting the emitter of said first conduction transistor to the emitter of said NPN transistor and the collector of the first conduction transistor to the emitters of the transistors comprising the first differential amplifier means, means connecting the second conduction transistor means between the emitters of said transistors comprising the second differential amplifier means and said means for limiting the maximum frequency output of said voltage controlled oscillator means, and means for coupling the bases of the first and second conduction transistor means together.

14. The invention as set forth in claim 10 wherein said analog switch is set to discharge said reactance means when there is no emitter current in the first differential pair.

15. A system for sensing and amplifying electrical potentials generated in conjunction with cardiac activity or activity from a pulse generator designed to pace the heart for transmission to distant monitoring facilities comprising:

signal processing means, a plurality of electrodes connected to said signal processing means, the signal processing means including means for receiving and amplifying currents generated in conjunction with said potentials, control means for controlling said signal processing means, means connecting the control means to said signal processing means to activate the signal processing means at selected intervals and in selected sequences to conduct currents due to potentials sensed by combinations of the electrodes, means for providing an indication of information carried by currents amplified by said means for receiving and amplifying, power source means coupled to power the signal processing means and the control means, the power source means comprising a direct current power source and power source test means coupled to the power source for receiving a signal from the power source and for processing the power source signal to generate a power source status output signal to said signal processing means, means for transmitting the power source status output to said monitoring facilities at selected time intervals, said control means providing signals to said signal processing means to ground a selected one of the other electrodes during the state of conduction for each pair of electrodes.

16. A cardiac monitoring system comprising a plurality of electrodes adapted to be coupled to the body of a patient for providing signals, means for generating an output signal, timing means for gating signals from the electrodes to the means for generating an output signal, the means for generating an output signal being operative to generate output signals representing the signals derived from the plurality of electrodes and providing the output signals to indicator means and comprising a voltage controlled oscillator including means including a first pair of transistors coupled to form first differential amplifier, the first differential amplifier being normally balanced, means coupling the first differential amplifier to be unbalanced by the presence of the signals derived from the electrodes, a capacitor and a resistor coupled between a common power supply and different ones of the first pair of transistors, means including a second pair of transistors coupled to form a second differential amplifier, means coupling the transistors of the second pair to different ones of the transistors of the first pair to provide operation of the second differential amplifier in response to the first differential amplifier, an output, at least one amplifier coupled between the second differential amplifier and the output, means coupled between the at least one amplifier and the first differential amplifier for controlling the current in the first pair of transistors, and means for periodically discharging the capacitor.

17. A biological monitoring system comprising:

sensor means for generating at least two sensor signals in response to biological actions;

means coupled to receive the sensor signals and providing a high input impedance for each said sensor signal, said means including amplifier means for generating intermediate signals in response to the sensor signals, and a field effect transistor for generating final signals in response to the intermediate signals, the field effect transistor being coupled to the amplifier means;

processing means responsive to the final signals for processing said signals and including differential amplifier means coupled to the field effect transistor for providing a differential signal in response to the difference between the final signals, and voltage controlled oscillator means for providing a signal which varies in frequency in response to the differential signal;

indicator means responsive to the processed signals for providing an indication of information carried by the processed signals;

conductor means coupled to pass the sensor signals to the means providing a high input impedance;

shield means arranged to shield the conductor means against common mode signals; and

means coupled to said shield means for exciting the shield means with a shield signal relating to the sensor signals to reduce capacitive coupling between the conductor means and the shield means.

18. The invention as set forth in claim 17, wherein there are four of said sensor means and wherein said amplifier means compirses five buffer amplifiers, the first sensor means being adapted to be attached to the manubrium of a patient and electrically connected to a first one of the five buffer amplifiers, the second sensor means being adapted to be attached to the left clavicle of a patient and connected to second and third ones of the five buffer amplifiers, the third sensor means being adapted to be attached in the region of the V₅ position and connected to a fourth one of the five buffer amplifiers, and the fourth sensor means being adapted to the attached in the region of the V₁ position and connected to a fifth one of the buffer amplifiers, and further including sequencing means coupled to and controlling the buffer amplifiers to sequentially render selective ones of the buffer amplifiers conductive, said sequencing means being operative to select two of the buffer amplifiers to be connected to the differential amplifier means while selecting a third of the buffer amplifiers to be connected as a ground means, and thereafter selecting another two of the buffer amplifiers to be connected to the differential amplifier means while selecting one of the buffer amplifiers formerly connected to the differential amplifier means to be connected as the ground means.

19. The invention as set forth in claim 17, wherein there are four of said sensor means, the first one of the four sensor means being adapted to be attached to the left side of the upper chest, the second one of the four sensor means being adapted to be attached to the right side of the upper chest, the third one of the four sensor means being adapted to be attached to the lower left quadrant of the abdomen, and a fourth one of the four sensor means being adapted to be attached in the region of the V₁ position.

20. A biological monitoring system comprising:

sensor means for generating at least one sensor signal in response to biological action;

conductor means for conducting the sensor signal;

shield means for shielding said conductor means;

signal processor means for generating an output signal in response to the conducted sensor signal;

indicator means responsive to the output signal for providing an indication of information carried by the output signal; and

feedback means for exciting said shield means in response to the conducted sensor signal to increase impedance of said conductor means.

21. The system as set forth in claim 20 above wherein said feedback means includes means for exciting said shield means to reduce capacitive coupling between said conducting means and said shield means.

22. The invention as set forth in claim 20, wherein the sensor means comprise electrode means for generating a plurality of sensor signals in response to cardiac action, said electrode means including at least three electrodes, and the signal processing means includes select means for generating select signals, said select means including for generating a first select signal to select a first output signal, means for generating a ground signal and means for generating a second select signal to select a second output signal, first signal processing means for generating the first output signal in response to the first select signal, said first signal processing means including means for generating the output signal in response to a difference between signals from a first pair of said electrodes in response to the first select signal and means for connecting the ground signal to a first ground electrode in response to the first select signal, and second signal processing means for generating the second output signal in response to the second select signal, said second signal processing means including means for generating the output signal in response to a difference between signals from a second pair of said electrodes in response to the second select signal and means for connecting the ground signal to a second ground electrode in response to the second select signal wherein said second ground electrode is included in said first pair of said electrodes, and further including monitoring means for monitoring an output signal in response to the select signals.

23. The invention as set forth in claim 20, wherein the sensor means comprises four electrodes, the first electrode being adapted to be attached to the left shoulder of a patient, the second electrode being adapted to be attached to the right shoulder of a patient, the third electrode being adapted to be attached to a patient in the area of the V₅ position, and the fourth electrode being adapted to be attached to a patient in the area of the V₁ position.

24. The invention as set forth in claim 20, wherein the sensor means generates a plurality of sensor signals in response to biological action and further including means responsive to the sensor signals for providing an indication of information carried thereby, means for processing said sensor signals, said means for processing having a saturated level, means for electronically switching to each of said sensor signals for a selected period of time in a given sequence in a repetitive cycle, means for generating a synchronization pulse marking the beginning of each repetitive cycle, each synchronization pulse having a predetermined magnitude related to the saturated level of said procesing means, means for settling out the transient signal variations accompanying switching in a time period which is small relative to said selected period of time for each of said sensor signals, means for transmitting said processed signals and each occurrence of the syncchronization pulse, and means responsive to the transmitted processed signals and each occurrence of the synchronization pulse for providing an indication of each occurrence of the synchronization pulse.

25. A cardiac monitoring system comprising the combination of:

means adapted to be responsive to cardiac activity of a patient for generating a first signal having horizontal EKG cardiac signal information;

means adapted to be responsive to cardiac activity of a patient for generating a second signal having vertical cardiac signal information;

means adapted to be responsive to cardiac activity of a patient for generating a third signal having anterior-posterior cardiac information as well as precordial information in the vicinity of the heart apex;

means adapted to be responsive to cardiac activity of a patient for generating a fourth signal having V₅ precordial information as well as transthoracic information, the fourth signal containing about 90% of the ischemic information of a conventional 12 lead EKG; and

means responsive to the first, second, third and fourth signals for processing said signals to provide an indication of cardiac activity.

26. A method for obtaining data on the cardiac action of a patient comprising the steps of:

coupling first electrode means to the right side of the manubrium of the patient;

coupling second electrode means to the outer left clavicle of the patient;

coupling third electrode means to the patient substantially at the V₅ position;

coupling fourth electrode means to the patient substantially at the V₁ position;

successively coupling different combinations of three of the first, second, third and fourth electrode means to provide cardiac signals, the cardiac signals comprising the difference between signals on two of the electrode means of each combination of three with the third electrode means of the combination of three being coupled as a grounded reference; and

providing a display of cardiac information carried by the cardiac signals.

27. The invention as set forth in claim 26, wherein the step of successively coupling includes coupling the first and second electrode means to provide a cardiac signal and one of the third and fourth electrode means as a grounded reference, coupling the first and third electrode means to provide a cardiac signal and one of the second and fourth electrode means as a grounded reference, coupling the second and third electrode means to provide a cardiac signal and one of the first and fourth electrode means as a grounded reference, and coupling the second and fourth electrode means to provide a cardiac signal and one of the first and third electrode means as a grounded reference.

28. A system for processing electrical currents due to potentials accompanying cardiac action of an ambulatory patient or electrical impulses from a pulse generator designed to pace the heart for multiplex transmission to monitoring facilities, comprising:

a plurality of electrodes adapted to electrically contact the body of a patient, amplifying means for amplifying signals fed thereto, means coupled to the amplifying means for providing an indication of information carried by amplified signals from the amplifying means, a plurality of buffer amplifier means coupled between the amplifying means and the electrodes, sequencing means coupled to and controlling the buffer amplifier means, the sequencing means including means for rendering selected ones of the buffer amplifier means conductive to pass signals to the amplifying means, and hole means for preventing operation of the sequencing means to continue passage of signals by the buffer amplifier means to the amplifying means in response to potentials from selected ones of the electrodes.

29. A cardiac monitoring system comprising the combination of:

means responsive to cardiac activity of a patient for generating a first signal having horizontal EKG cardiac signal information;

means responsive to cardiac activity of a patient for generating a second signal having vertical cardiac signal information;

means responsive to cardiac activity of a patient for generating a third signal having anterior-posterior cardiac information and heart apex precordial information;

means responsive to cardiac activity of a patient for generating a fourth signal having V₅ precordial information and transthoracic information; and

means responsive to the first, second, third and fourth signals for processing said signals to provide an indication of cardiac activity.