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Method for making a microsealed delivery device

  • US 3,992,518 A
  • Filed: 09/29/1975
  • Issued: 11/16/1976
  • Est. Priority Date: 10/24/1974
  • Status: Expired due to Term
First Claim
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1. a method for constructing a biologically acceptable silicone polymer matrix adapted for placement in silicone polymer or ethylene/vinylacetate copolymer tubing having 10-200 micron microsealed compartments distributed throughout, said microsealed compartments containing a pharmaceutical in a hydrophilic solvent system impermeable to said polymer tubing, comprising:

  • a. emulsifying the hydrophilic solvent system of water and liquid polyethylene glycol containing the pharmaceutical and biologically acceptable room-temperature Vulcanizing liquid polydimethylsiloxane silicone polymer andb. in situ cross-linking the biologically acceptable liuqid silicone polymer to form the biologically acceptable silicone polymer matrix with microsealed compartments throughout containing pharmaceutical and hydrophilic solvent system.

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