Serial preparation of narrow traces of cellular biological fluids
First Claim
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1. In a method of laying serially traces of a generally cellular biological fluid on the surface of a trace receiving means comprising a flexible continuous transparent film which comprises with regard to each trace the improvement comprising the steps of:
- a. depositing a discrete quantity of said fluid in the form of a sessile drop on the surface of said receiving means, thereby forming a discrete pool of fluid;
b. contacting said fluid pool with a fluid extending means having a fine tip to establish a liquid index of said pool of fluid between said tip of said extending means and the surface of said trace receiving means; and
c. moving said fluid extending means and said receiving means relative to each other, whereby said fluid is retained between the surface of said receiving means and said extending means to effect a narrow trace of gradually thinning-out width of said fluid on said surface of said receiving means.
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Abstract
Apparatus and method are described for preparing a narrow trace of physiological fluid on a substrate from a discrete fluid pool. The trace so produced is substantially identical to traces manually prepared in that they are characterized by distinct macroscopic and microscopic zones. Automatic trace staining apparatus also is provided.
25 Citations
5 Claims
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1. In a method of laying serially traces of a generally cellular biological fluid on the surface of a trace receiving means comprising a flexible continuous transparent film which comprises with regard to each trace the improvement comprising the steps of:
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a. depositing a discrete quantity of said fluid in the form of a sessile drop on the surface of said receiving means, thereby forming a discrete pool of fluid; b. contacting said fluid pool with a fluid extending means having a fine tip to establish a liquid index of said pool of fluid between said tip of said extending means and the surface of said trace receiving means; and c. moving said fluid extending means and said receiving means relative to each other, whereby said fluid is retained between the surface of said receiving means and said extending means to effect a narrow trace of gradually thinning-out width of said fluid on said surface of said receiving means. - View Dependent Claims (2, 3, 4, 5)
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Specification