Ocular insert

• US 3,995,635 A
• Filed: 11/04/1974
• Issued: 12/07/1976
• Est. Priority Date: 09/09/1971
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Shell, John W., Hussain, Anwar A., Higuchi, Takeru
• Primary Examiner(s): Medbery, Aldrich F.
• Application Number:
  US05/520,277
• Time in Patent Office: 764 Days
• Field of Search: 128/260, 128/261, 128/156, 424/15, 424/19-22, 206/.5
• US Class Current: 424/427
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

A drug-dispensing ocular insert containing a drug and suited for application to the eyeball to dispense said drug to the eye over a prolonged period of time, includes, for permitting facile insertion into and comfortable retention within the eye, and more importantly for preventing the accidental expulsion of the insert therefrom, first detent means adapted for insertion into the cul-de-sac of the conjunctiva between the sclera of the eyeball and the upper eyelid, and second, conjoint detent means, cooperative with said first detent means, adapted for insertion into the cul-de-sac of the conjunctiva between the said sclera of the eyeball and the lower eyelid.

Claims

1. In a non-corneal, drug dispensing ocular insert comprising a flexible body containing a drug for application to the eyeball to dispense said drug to the eye over a prolonged period of time, the improvement comprising a means for permitting facile insertion into and comfortable retention within the eye, and concomitantly preventing the expulsion of the insert therefrom, wherein said flexible body comprises an annular ring that is sized relative to the eye so it can be placed about the eyeball and in contact therewith, completely posterior to the sulcus sclerae and within the upper and lower cul de sacs, the width of the ring being such that the ring is virtually invisible in the palpebral fissure when the eyelids are open.

2. The ocular insert as defined by claim 1, wherein the annular ring is peripherally elliptical in shape, and is thin and flattened.

3. The ocular insert as defined by claim 2, wherein the annular ring is bowed to the configuration of the scleral curvature.

4. The ocular insert as defined in claim 2 wherein said width is 2 to 8 mm.

5. The ocular insert as defined by claim 1, containing an ophthalmic drug.

6. The ocular insert as defined by claim 1, containing a systemically active drug which will pass through the eye to the bloodstream and elicit a pharmacologic response at a site remote from the eye.

7. The ocular insert as defined in claim 1 wherein said width is about 1 to 12 mm.

8. In a non-corneal, drug dispensing ocular insert comprising a flexible body containing a drug for application to the eyeball to dispense said drug to the eye over a prolonged period of time, the improvement for permitting facile insertion into and comfortable retention within the eye, and concomitantly preventing the expulsion of the insert therefrom, wherein the said flexible body comprises a lunular ring that is sized relative to the eye so it can be placed partly about the eyeball and in contact therewith, completely posterior to the sulcus sclerae and within the upper and lower cul de sacs, the width of the ring being such that the ring is virtually invisible in the palpebral fissure when the eyelids are open.

9. The ocular insert as defined in claim 8 wherein said width is about 1 to 12 mm.

10. The ocular insert as defined in claim 8 wherein said width is about 2 to 8 mm.

11. The ocular insert as defined in claim 8, containing an ophthalmic drug.

12. The ocular insert as defined in claim 8, containing a systemically active drug which will pass through the eye to the bloodstream and elicit a pharmacologic response at a site remote from the eye.

13. The ocular insert as defined by claim 8, wherein the lunular ring is bowed to the configuration of the scleral curvature.