Freeze-drying process

• US 4,001,944 A
• Filed: 08/25/1975
• Issued: 01/11/1977
• Est. Priority Date: 08/25/1975
• Status: Expired due to Term

• Current Assignee: Parke Davis & Company Limited (Pfizer Inc.)
• Original Assignee: Parke Davis & Company Limited (Pfizer Inc.)
• Inventors: Williams, David C.
• Primary Examiner(s): Camby, John J.
• Application Number:
  US05/607,306
• Time in Patent Office: 505 Days
• Field of Search: 34/5, 34/92, 165/185
• US Class Current: 34/285
• CPC Class Codes: A01N 1/0252 Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
• CPC Class Codes: A01N 1/0284 Temperature processes, i.e. using a designated change in temperature over time
• CPC Class Codes: F26B 5/06 the process involving freezing

Abstract

A process is provided for freeze-drying an aqueous liquid product which comprises distributing the liquid product in containers closely fitted in cavities of a tray-shaped heat-conducting solid metal block having relatively high heat transfer, subjecting the block to accelerated cooling such that the liquid in each container is frozen thereby freezing the liquid in each container at substantially the same rate, and drying the frozen product under vacuum while in the block so that the frozen product in each container is dried at substantially the same rate.

Claims

1. The process of freeze-drying parenteral aqueous liquid by means of a tray-shaped unitary block of heat-conducting metal having a plurality of spaced cavities therein each adapted to receive a container supported in a close fit so that the spacing between the containers is occupied substantially only by the heat-conducting metal, comprising the steps of

distributing said liquid within containers in cavities of the block to a depth such that for heat transfer the body of liquid in each container is substantially confined within the block,

subjecting the block to nitrogen bath cooling to freeze the liquid in a short period less than about one hour, thereby freezing the liquid in each container at substantially the same rate,

and drying the frozen product under vacuum while confined within the block so that the frozen product in each container is dried in less than about 41/2 days at substantially the same rate.

2. The process according to claim 1 where the heat-conducting metal is aluminum.

3. The process according to claim 1 where cooling is carried out in a zone maintained at temperatures in the range from about -320°

to -220°

F.

4. The process according to claim 1 where the aqueous liquid is a biological product.

5. The process according to claim 1 where the aqueous liquid is a blood product.

6. The process according to claim 1 where the aqueous liquid contains anti-hemophilic factor.