Analysis apparatus and method of measuring rate of change of electrolyte pH
First Claim
1. In combination:
- sensor means for monitoring a chemically reactable substance, said sensor means including an electrolyte which undergoes a chance in pH with time upon reaction with said substance,means coupled to said sensor means for generating an output signal proportional to the instantaneous time rate of change of pH of said electrolyte; and
means for measuring said output signal to determine the concentration of said substance in said electrolyte.
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Accused Products
Abstract
Apparatus for measuring carbon dioxide and chloride in blood. A blood sample is reacted with acid in a sample container to release carbon dioxide, a portion of which diffuses through a gas-permeable membrane and reacts with an electrolyte to change the pH thereof. A pair of pH measuring electrodes monitor the electrolyte pH at respective locations adjacent to and remote from the region of reaction within the electrolyte. The pH electrodes are coupled to respective input terminals of a differential amplifier to derive a differential pH signal. The differential pH signal is differentiated to derive a rate of change of pH output signal which is measured to indicate the concentration of carbon dioxide. The pH measuring electrodes are in electrolytic communication and means is provided to renew the electrolyte between measurements. Coulometric measurement of chloride in the sample is performed simultaneously with the carbon dioxide measurement.
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Citations
21 Claims
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1. In combination:
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sensor means for monitoring a chemically reactable substance, said sensor means including an electrolyte which undergoes a chance in pH with time upon reaction with said substance, means coupled to said sensor means for generating an output signal proportional to the instantaneous time rate of change of pH of said electrolyte; and means for measuring said output signal to determine the concentration of said substance in said electrolyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An analytical method for measuring a substance by reacting said substance with an electrolyte comprising the steps of:
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monitoring the pH of said electrolyte and generating an output signal proportional to the instantaneous time rate of change of the pH of said electrolyte upon reaction with said substance; and measuring said output signal to determine the concentration of said substance. - View Dependent Claims (17, 18, 19, 20)
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21. An analytical method for analyzing a blood sample for bicarbonate and chloride including the steps of:
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reacting said sample with a reagent in a container means to release carbon dioxide therefrom; reacting said carbon dioxide with an electrolyte which undergoes a change in pH upon reaction therewith; monitoring the pH of said electrolyte and generating an output signal proportional to the instantaneous time rate of change of said pH; measuring said output signal to determine carbon dioxide concentration; and simultaneously coulometrically titrating said sample in said container means with silver ions to measure the chloride therein.
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Specification