Derivatives of imidazo(4,5-b)pyridines

• US 4,003,908 A
• Filed: 03/11/1976
• Issued: 01/18/1977
• Est. Priority Date: 03/11/1976
• Status: Expired due to Term

• Current Assignee: E R Squibb & Sons Incorporated
• Original Assignee: E R Squibb & Sons Incorporated
• Inventors: Denzel, Theodor, Hoehn, Hans
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US05/665,754
• Time in Patent Office: 313 Days
• Field of Search: 260/295.5 B, 260/294.8 R
• US Class Current: 546/118
• CPC Class Codes: C07D 213/80 in position 3

Abstract

Derivatives of imidazo[4,5-b]pyridines having the general formula ##STR1## are disclosed. The novel compounds are useful as central nervous system depressants and anti-inflammatory agents.

Claims

1. A compound of the formula ##STR54##wherein R is hydrogen or lower alkyl;

R¹ is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl or cyclo-lower alkyl;

R² is hydrogen, lower alkyl, phenyl or phenyl-lower alkyl;

R³ is lower alkyl or lower alkenyl;

R⁴ is hydrogen, lower alkyl or phenyl; and

physiologically acceptable salts thereof.

2. A compound as in claim 1 wherein R¹ is lower alkyl.

3. A compound as in claim 1 wherein R³ is lower alkyl.

4. A compound as in claim 1 wherein R and R² each is hydrogen or lower alkyl;

R¹ and R³ each is lower alkyl; and

R⁴ is lower alkyl or phenyl.

5. A compound as in claim 1 wherein R, R¹, R², R³ and R⁴ each is lower alkyl.

6. A compound as in claim 1 wherein R, R¹ and R⁴ each is lower alkyl and R² is hydrogen.

7. A compound as in claim 1 wherein R and R¹ each is ethyl, R² is hydrogen, R⁴ is methyl and R³ is lower alkyl.

8. A compound as in claim 7 wherein R³ is ethyl.

9. A compound as in claim 7 wherein R³ is 1-methylethyl.

10. A compound as in claim 7 wherein R³ is butyl.

11. A compound as in claim 7 wherein R³ is 3-methylbutyl.

12. A compound as in claim 1 wherein R and R³ each is ethyl, R¹ and R⁴ each is methyl and R² is hydrogen.

13. A compound as in claim 1 wherein R and R³ each is ethyl, R¹ is butyl, R² is hydrogen and R⁴ is methyl.

14. A compound as in claim 1 wherein R is ethyl, R¹ and R⁴ each is methyl, R² is hydrogen and R³ is 3-methylbutyl.