Delayed release pharmaceutical preparations

• US 4,013,784 A
• Filed: 10/02/1974
• Issued: 03/22/1977
• Est. Priority Date: 12/06/1973
• Status: Expired due to Term

• Current Assignee: Peter Speiser
• Original Assignee: Peter Speiser
• Inventors: Speiser, Peter
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/511,174
• Time in Patent Office: 902 Days
• Field of Search: 424/19-22
• US Class Current: 424/502
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/2013 Organic compounds, e.g. phospholipids, fats

Abstract

A novel delayed release pharmaceutical preparation which is free of added enzymes and thus is stable on storage is provided. The preparation comprises particles of the therapeutically effective agent, a water-soluble calcium salt, and, if desired, a filler material, stabilizer, and other additives uniformly embedded in a triglyceride of fatty acids with 12 to 18 carbon atoms, thereby forming a granular preparation of a grain size between about 0.1 mm. and about 1.0 mm. A process of producing such a preparation is also disclosed.

Claims

1. A delayed release pharmaceutical preparation in granular form comprising intermixed particles of at least one orally administrable therapeutically active agent and a substantially non-toxic water-soluble calcium salt selected from the group consisting of calcium levulinate, calcium gluconate, calcium citrate and calcium chloride, at least part of said particles of said agent and said salt being enveloped by solidifying a melt of at least one triglyceride of a fatty acid of 12 to 18 carbon atoms, said salt being present in an amount to provide at least 11/2 moles of calcium ion for each mole of said triglyceride and forming a substantially insoluble calcium soap with the fatty acid produced upon hydrolysis of said triglyceride in the intestinal tract, the granules of said preparation being of a grain size between about 0.1 mm. and about 1.0 mm. and containing between about 1 and 50% of said agent.

2. The pharmaceutical preparation of claim 1, wherein the triglyceride is selected from the group consisting of trilaurin, trimyristin, tripalmitin, and mixtures of said triglycerides.

3. The pharmaceutical preparation of claim 1, wherein the fatty acid triglyceride is present in the form of its β

-modification.

4. The pharmaceutical preparation of claim 1, wherein the proportion of therapeutically active agent and calcium salt to fatty acid triglyceride in the preparation is between about 5% and about 30% by volume.

5. The pharmaceutical preparation of claim 1, wherein the preparation is in the form of spherical pellets of a diameter between about 0.1 mm. and about 1 mm. and wherein the ratio of the particle size of the active agent to the size of the pellet is between about 1 :

20 and about 1 ;

100.

6. The pharmaceutical preparation of claim 1, additionally containing physiologically inert filler materials.

7. The pharmaceutical preparation of claim 1, additionally containing physiologically inert filler materials, preserving agents, stabilizers, aroma imparting and taste improving agents, and disintegration promoting agents.

8. A delayed release pharmaceutical composition having the preparation of claim 1 enclosed in a gelatin capsule.

9. A delayed release pharmaceutical composition in readily disintegrating tablet form containing the preparation of claim 1 and conventional tabletting adjuvants.

10. A delayed release pharmaceutical composition in aqueous dispersion form containing the granules of the preparation of claim 1 suspended in an aqueous medium containing a physiologically compatible, viscosity increasing agent.