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Laminated osmotic system for dispensing beneficial agent

  • US 4,014,334 A
  • Filed: 02/02/1976
  • Issued: 03/29/1977
  • Est. Priority Date: 02/02/1976
  • Status: Expired due to Term
First Claim
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1. An osmotic system for the controlled and continuous dispensing of a beneficial agent to an environment of use, said system comprising:

  • a. a shaped wall comprising a laminate, said laminate comprising a semipermeable lamina that is permeable to the passage of an external fluid and which lamina substantially maintains its physical and chemical integrity in the environment of use; and

    a semipermeable lamina that is permeable to the passage of an external fluid, substantially impermeable to the passage of agent and which lamina substantially maintains its physical and chemical integrity in the presence of fluid and agent, said wall surrounding;

    b. a compartment containing the beneficial agent;

    c. a passageway in the wall communicating with the compartment and the exterior of the system for dispensing agent from the system; and

    d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the wall into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously dissolving agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time.

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