Laminated osmotic system for dispensing beneficial agent
First Claim
1. An osmotic system for the controlled and continuous dispensing of a beneficial agent to an environment of use, said system comprising:
- a. a shaped wall comprising a laminate, said laminate comprising a semipermeable lamina that is permeable to the passage of an external fluid and which lamina substantially maintains its physical and chemical integrity in the environment of use; and
a semipermeable lamina that is permeable to the passage of an external fluid, substantially impermeable to the passage of agent and which lamina substantially maintains its physical and chemical integrity in the presence of fluid and agent, said wall surrounding;
b. a compartment containing the beneficial agent;
c. a passageway in the wall communicating with the compartment and the exterior of the system for dispensing agent from the system; and
d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the wall into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously dissolving agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time.
0 Assignments
0 Petitions
Accused Products
Abstract
An osmotic system for delivering a beneficial agent to an environment of use is disclosed. The system comprises a laminate surrounding a compartment and has a passageway through the laminate for releasing agent from the compartment. The laminate comprises at least two laminae; one consisting of a semipermeable, polymeric material that is permeable to the passage of an external fluid and maintains its physical and chemical integrity in the environment of use, and one consisting of a semipermeable polymeric material that is permeable to the passage of the fluid, substantially impermeable to the passage of agent and maintains its physical and chemical integrity in the presence of agent. The compartment comprises an active agent that is either soluble in the external fluid and exhibits an osmotic pressure gradient across the laminate against the fluid, or the agent has limited solubility in the fluid and it is mixed with an osmotically effective compound that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid. In operation, agent is released from the system by fluid being imbibed through the laminate into the compartment at a rate controlled by the permeability of the laminate and the osmotic pressure gradient across the laminate producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.
-
Citations
36 Claims
-
1. An osmotic system for the controlled and continuous dispensing of a beneficial agent to an environment of use, said system comprising:
-
a. a shaped wall comprising a laminate, said laminate comprising a semipermeable lamina that is permeable to the passage of an external fluid and which lamina substantially maintains its physical and chemical integrity in the environment of use; and
a semipermeable lamina that is permeable to the passage of an external fluid, substantially impermeable to the passage of agent and which lamina substantially maintains its physical and chemical integrity in the presence of fluid and agent, said wall surrounding;b. a compartment containing the beneficial agent; c. a passageway in the wall communicating with the compartment and the exterior of the system for dispensing agent from the system; and d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the wall into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously dissolving agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. An osmotic system for the controlled and continuous dispensing of a beneficial agent to an environment of use, said system comprising:
-
a. a shaped laminate that is permeable to the passage of an external fluid and substantially impermeable to the passage of agent, said laminate comprising a pair of laminae, with one lamina consisting of a semipermeable material that is essentially non-erodible and exhibits substantial inertness to compounds and fluids present in the environment of use, and with one lamina consisting of a semipermeable material that is essentially non-erodible and exhibits substantial inertness to fluid and agent; b. the laminate surrounding and forming a compartment containing the beneficial agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the laminate against the fluid; c. a passageway in the laminate communicating with the compartment and the exterior of the system for dispensing agent from the system; and d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the laminate into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the laminate and the osmotic pressure gradient across the laminate, thereby continuously dissolving agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. An osmotic system for the controlled and continuous dispensing of a beneficial agent to an environment of use, said system comprising:
-
a. a shaped laminate comprising two laminae, with one lamina consisting of a semipermeable material that is permeable to the passage of an external fluid, substantially impermeable to compounds present in the environment of use, and substantially maintains its physical and chemical integrity in the environment of use, and with one lamina consisting of a semipermeable material that is permeable to the passage of an external fluid, substantially impermeable to the passage of agent and compounds present in the environment of use, and substantially maintains its physical and chemical integrity in the presence of fluid and agent; b. the laminate surrounding and forming a compartment containing the agent; c. a passageway in the laminate communicating with the compartment and the exterior of the system for dispensing agent from the system; and d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the laminate into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the laminate and the osmotic pressure gradient across the laminate, thereby forming a solution containing agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32)
-
-
33. An osmotic system for the controlled and continuous dispensing of an active agent to an environment of use, said system comprising:
-
a. a compartment containing an active agent; b. a shaped laminated wall surrounding and forming the compartment, said wall formed of a plurality of semipermeable laminae comprising a lamina positioned adjacent to the compartment that maintains its physical and chemical integrity in the presence of agent, and a lamina positioned distant from the compartment that faces the environment and maintains its physical and chemical integrity when the system is in the environment; c. a passageway in the laminated wall communicating with the compartment and the exterior of the system for dispensing agent from the system; and
,d. wherein in operation when the system is in the environment of use, fluid from the environment is continuously imbibed through the laminated wall into the compartment in a tendency towards osmotic equilibrium at a rate determined by the permeability of the laminated wall and the osmotic pressure gradient across the wall, thereby continuously dissolving agent that is dispensed through the passageway at a controlled and continuous rate over a prolonged period of time. - View Dependent Claims (34, 35, 36)
-
Specification