Cholesteric liquid crystalline phase material-dye composition and venapuncture method employing the composition

• US 4,015,591 A
• Filed: 02/17/1976
• Issued: 04/05/1977
• Est. Priority Date: 02/17/1976
• Status: Expired due to Term

• Current Assignee: Liquid Crystal Products Incorporated
• Original Assignee: Liquid Crystal Products Incorporated
• Inventors: Davison, Thomas W., Suzuki, Fred K.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US05/658,407
• Time in Patent Office: 413 Days
• Field of Search: 128/2 F, 128/2 G, 128/2 H, 128/2 R, 128/399, 128/DIG. 5, 73/356, 252/408 LC, 23/230 LC
• US Class Current: 600/549
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61M 5/32 Needles; Details of needles pertaining to their connection with syringe or hub infusion needles A61M5/158; Accessories for bringing the needle into, or holding the needle on, the body A61M5/42, A61M5/46 take precedence; guide needles for catheters A61M25/065; Devices for protection of needles apparatus specially adapted for cleaning or sterilising needles A61M5/001
• CPC Class Codes: A61M 5/427 Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
• CPC Class Codes: C09K 19/60 Pleochroic dyes
• CPC Class Codes: G01K 11/165 of organic liquid crystals

Abstract

A composition of matter having thermal color responsive characteristics and adapted for exhibiting improved color contrast includes an enantiotropic cholesteric liquid crystalline phase material, and at least two oil-soluble dyes dissolved in the material in a total dye concentration of 0.01-1% by weight of the composition, each of the dyes reflecting light of a different wave length in the range of 400 to 700 nanometers, and said dyes together absorbing light of substantially all wave lengths within said range. A method of effecting venapuncture in the human body includes the steps of cooling the skin over a venous area, applying directly on the skin a layer of the composition about 100 to 300 microns thick, allowing the skin over the venous area to rewarm due to venous blood flow, until the said material exhibits a mesophase color change to thereby delineate a vein therebeneath, and directing an instrument for venapuncture to a site in the said area indicated by the delineation to constitute the location of a vein.

Claims

1. A composition of matter having thermal color responsive characteristics and adapted for exhibiting improved color contrast which comprises an enantiotropic cholesteric liquid crystalline phase material, and at least two oil-soluble dyes dissolved in said material in a total dye concentration of 0.01-1% by weight of the composition, each of said dyes reflecting light of a different wave length in the range of 400 to 700 nanometers, and said dyes together absorbing light of substantially all wave lengths within said range.

2. A composition as defined in claim 1 wherein said dyes together exhibit a violet, brown, or brown-black color at room temperature.

3. A composition as defined in claim 2 wherein said dyes are selected from the group consisting of dyes having the Color Index designations:

Solvent Yellow 5, Solvent Yellow 30, Solvent Yellow 33, Solvent Orange 2, Solvent Orange 17, Solvent Red 23, Solvent Red 27, Solvent Red 49, Solvent Green 3, Solvent Green 7, Solvent Violet 13, and Solvent Violet 17.

4. A composition as defined in claim 3 wherein said material is selected from the group consisting of cholesteryl, dicholesteryl, cholestanyl, and sitosteryl organic esters, halides, and alkyl carbonates.

5. A composition as defined in claim 4 in the form of an organic solvent-free paste.

6. A composition as defined in claim 5 wherein said dyes comprise a mixture of about 0.1% C.I. Solvent Violet 13, 0.02-0.05% C.I. Solvent Yellow 33, and 0.02-0.05% C.I. Solvent Red 23, in percentages by weight of said composition.

7. A layer of the composition of claim 6 having a thickness of about 100 to 300 microns, said layer exhibiting improved color contrast and high color intensity.

8. A composition as defined in claim 1 having a mesophase temperature range in the range of 25°

-40°

C.

9. A composition as defined in claim 1 wherein said material is selected from the group consisting of cholesteryl, dicholesteryl, cholestanyl, and sitosteryl organic esters, halides, and alkyl carbonates.

10. A composition as defined in claim 1 in the form of an organic solvent-free paste.

11. A layer of the composition of claim 1 having a thickness of about 100 to 300 microns, said layer exhibiting improved color contrast and high color intensity.

12. A method of effecting vanapuncture in the human body which comprises:

a. in any order, (1) cooling the skin over a venous area of the body, and (2) applying directly on the skin over said area a layer about 100 to 300 microns thick of a composition having thermal color responsive characteristics, said layer exhibiting improved color contrast and high color intensity, said composition comprising an enantiotropic cholesteric liquid crystalline phase material exhibiting a mesophase color change at a temperature reached by the skin upon rewarming due to venous blood flow, and at least two oil-soluble dyes dissolved in said material in a total dye concentration of 0.01-1% by weight of the composition, each of said dyes reflecting light of a different wave length in the range of 400 to 700 nanometers, and said dyes together absorbing light of substantially all wave lengths within said range;

b. allowing the skin over said area to rewarm due to venous blood flow, until said material exhibits a mesophase color change to thereby delineate a vein therebeneath; and

c. directing an instrument for venapuncture to a site in said area indicated by said delineation to constitute the location of a vein.

13. A method as defined in claim 12 wherein the mesophase temperature range of said material falls within the range of 25°

-40°

C, and the skin temperature following said cooling is below said mesophase temperature range.

14. A method as defined in claim 12 wherein the mesophase temperature range of said material is about 31°

-34°

C, and the skin temperature following said cooling is about 25°

-28°

C.

15. A method as defined in claim 12 wherein said dyes together exhibit a violet, brown, or brown-black color at room temperature.

16. A method as defined in claim 12 wherein said material is selected from the group consisting of cholesteryl, dicholesteryl, cholestanyl, and sitosteryl organic esters, halides, and alkyl carbonates.

17. A method as defined in claim 12 wherein said dyes are selected from the group consisting of dyes having the Color Index designations:

Solvent Yellow 5, Solvent Yellow 30, Solvent Yellow 33, Solvent Orange 2, Solvent Orange 17, Solvent Red 23, Solvent Red 27, Solvent Red 49, Solvent Green 3, Solvent Green 7, Solvent Violet 13, and Solvent Violet 17.

18. A method of effecting venapuncture in the human body which comprises:

a. in any order, (1) cooling the skin over a venous area of the body, and (2) applying directly on the skin over said area a layer about 100 to 300 microns thick of a composition having thermal color responsive characteristics and being in the form of an organic solvent-free paste, said layer exhibiting improved color contrast and high color intensity, said composition comprising an enantiotropic cholesteric liquid crystalline phase material having a mesophase temperature range within the range of 28°

-38°

C and exhibiting a mesophase color change at a temperature reached by the skin upon rewarming due to venous blood flow, the skin temperature following said cooling being below said mesophase temperature range, and at least two oil-soluble dyes dissolved in said material in a total dye concentration of 0.01-1% by weight of the composition, each of said dyes reflecting light of a different wave length in the range of 400 to 700 nanometers and being selected from the group consisting of dyes having the Color Index designations;

Solvent Yellow 5, Solvent Yellow 30, Solvent Yellow 33, Solvent Orange 2, Solvent Orange 17, Solvent Red 23, Solvent Red 27, Solvent Red 49, Solvent Green 3, Solvent Green 7, Solvent Violet 13, and Solvent Violet 17, and said dyes together absorbing light of substantially all wave lengths within said range and exhibiting a violet, brown, or brown-black color at room temperature;

b. allowing the skin over said area to rewarm due to venous blood flow, until said material exhibits a mesophase color change to thereby delineate a vein therebeneath; and

c. directing an instrument for venapuncture to a site in said area indicated by said delineation to constitute the location of a vein.

19. A method as defined in claim 18 wherein said material is selected from the group consisting of cholesteryl, dicholesteryl, cholestanyl, and sitosteryl organic esters, halides, and alkyl carbonates.

20. A method as defined in claim 19 wherein said dyes comprise a mixture of about 0.1% C.I. Solvent Violet 13, 0.02-0.05% C.I. Solvent Yellow 33, and 0.02-0.05% C.I. Solvent Red 23, in percentages by weight of said composition.