Sample supply apparatus and method for automatic analysis systems

• US 4,015,938 A
• Filed: 11/18/1975
• Issued: 04/05/1977
• Est. Priority Date: 11/18/1975
• Status: Expired due to Term

• Current Assignee: ALFA Laval AB
• Original Assignee: Technicon Instruments Corporation
• Inventors: Jay, Ronald Frank
• Primary Examiner(s): Serwin, R.E.
• Application Number:
  US05/633,059
• Time in Patent Office: 504 Days
• Field of Search: 23/259, 23/230 R, 23/253 R, 73/425.4 R, 73/425.6
• US Class Current: 73/864.22
• CPC Class Codes: G01N 35/08 using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
• CPC Class Codes: Y10T 436/118339 with formation of a segmented stream

Abstract

Method and apparatus for fluid supply for a continuous-flow analysis system which apparatus includes conduit means passing a stream segmented by an immiscible fluid, and a tube having an inlet portion movable out of and into an operative position a distance within the conduit in an upstream direction and being of a cross-sectional dimension which does not occlude the conduit.

Claims

1. Fluid supply apparatus for a continuous-flow system, comprising:

a conduit element, means flowing a liquid stream segmented by segments of an immiscible fluid along said conduit element, an off-take tube element having an inlet portion movable to first and second positions, means to move said inlet portion to said positions, said inlet portion in said first position being in fluid-flow communication with said stream and disposed within said conduit element, and aspirating means connected to said tube element and removing a portion of successive segments of said liquid and immiscible fluid, in turn, from said stream while said tube element is in said first position, said inlet portion being removed from said fluid-flow communication while in said second position.

2. Apparatus as defined in claim 1, wherein:

said tube inlet portion extends axially into said conduit element in said first position and is of a cross-sectional dimension which does not occlude said conduit element.

3. Apparatus as defined in claim 1, wherein:

said tube inlet portion in said second position is in fluid-flow communication with a different fluid, and said aspirating means aspirates said different fluid through said tube element.

4. Apparatus as defined in claim 2, wherein one of said elements has a protuberance restricting the flow in said conduit element and spaced a distance downstream from said tube inlet portion in said first position of said inlet portion, said segmenting fluid being a gas.

5. Apparatus as defined in claim 2, wherein said conduit element comprises an open funnel-shaped end guiding said tube element thereinto and through which said tube inlet portion extends.

6. Sample supply apparatus, comprising:

an aspirating off-take tube having an inlet portion;

a carrier for a plurality of upwardly opening receptacles each containing a liquid sample;

a wash liquid supply device laterally of said carrier, said supply device comprising a conduit of internal cross-sectional dimension to axially receive said tube inlet portion, said conduit having an open end, said supply device further comprising means flowing liquid segmented by gas segments along said conduit towards said conduit end; and

means including aspirating means moving said tube inlet portion into and out of successive ones of said receptacles and, alternately, into and out of said conduit end between successive movement into said receptacles to aspirate a number of successive liquid and gas segments, in turn, flowing along said conduit intermediate successive aspirations of said liquid samples.

7. Fluid supply apparatus, comprising:

a conduit having an outlet, a tube having an inlet portion, means flowing a stream of liquid segmented by immiscible fluid segments along said conduit toward said outlet, means intermittently moving said tube to axially position said inlet portion within said conduit and in fluid-flow communication with said stream, and aspirating means connected to said tube to aspirate a portion of said liquid segments and immiscible fluid segments, in turn, when said inlet portion is positioned within said conduit.

8. A method of obtaining for a continuous flow analysis system a stream of successive liquid segments separated by immiscible fluid segments, comprising the steps of:

flowing a stream of liquid separated by immiscible fluid segments along a conduit toward an outlet thereof;

intermittently positioning an inlet portion of a tube within said conduit and in fluid-flow communication with said stream; and

aspirating through said tube a portion of said successive liquid and immiscible fluid segments, in turn, when said inlet portion is positioned within said conduit.

9. A method as defined in claim 8, further including positioning said tube inlet portion axially within said conduit, and flowing the unaspirated portion of said stream along said conduit and beyond said inlet portion.

10. A method as defined in claim 8, further including positioning said tube inlet portion in a second position and in fluid-flow communication with a different source of fluid, and aspirating said fluid from said different source through said tube while said inlet portion is in said second position.

11. A method as defined in claim 8, further including positioning said tube inlet portion in said position to extend into said conduit with clearance, flowing the unaspirated portion of said stream beyond said inlet portion, and partially restricting the flow of said stream in said conduit at a location spaced downstream from said inlet portion.

12. A method as defined in claim 11, further including maintaining said inlet portion immersed in a liquid segment of said stream as said inlet portion is removed from said conduit.

13. A method as defined in claim 11, further including intermittently introducing said gas segments into liquid continuously flowing along said conduit to form said stream, and maintaining said tube inlet portion immersed in a liquid segment when a gas segment is introduced into said liquid.