Microcapsules in the nanometric range and a method for their production
First Claim
1. Microcapsules of encapsulated active material, said microcapsules being colloidally soluble in water, said capsules comprising a gel of polymerized acrylamide, polymerized N,N'"'"'-methylene-bis acrylamide, polymerized acrylic acid, or methyl acrylate, said microcapsules having a diameter in a micellar order of magnitude of 20-200 nanometers.
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Abstract
The present invention is concerned with novel synthetic capsules which are colloid soluble in water or suspendible or colloid soluble in hydrophobic media and consist of compatible polymeric material, more especially of acrylamide and N,N'"'"'-methylene-bis-acrylamide gel or of acrylic acid and acrylic acid methyl ester gel, which are submicroscopic and mainly micellar in size, and which contain biologically or pharmacodynamically active material, more especially proteins, antigens, pharmacologically or therapeutically active substances or pesticides, fertilizers, dyes, color forming agents, adhesives and catalysts or other technically active substances in an incorporated and/or adsorbed form, together with the method for their production and their application.
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Citations
7 Claims
- 1. Microcapsules of encapsulated active material, said microcapsules being colloidally soluble in water, said capsules comprising a gel of polymerized acrylamide, polymerized N,N'"'"'-methylene-bis acrylamide, polymerized acrylic acid, or methyl acrylate, said microcapsules having a diameter in a micellar order of magnitude of 20-200 nanometers.
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3. A process for the production of microcapsules of polymeric material having encapsulated active materials, said microcapsules being colloidally soluble in water and having a diameter in a micellar order of magnitude of 20-200 nanometers, said process comprising:
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(a) dissolving boundary surface-active auxiliary emulsifying substances in a hydrophobic liquid to form micellar reaction spaces in said hydrophobic liquids; (b) adding to said hydrophobic liquid while stirring, an aqueous solution of an active material to be encapsulated and an encapsulating monomer from the group consisting of acrylamide, N,N'"'"'-methylene-bis-acrylamide, acrylic acid, and methyl acrylate, said aqueous solution substantially assuming a presence in said micellar spaces; (c) polymerizing the micellarly dissolved monomers to form microcapsules having said active material absorbed and/or encapsulated in said microcapsules, said polymerization taking place in said micellar spaces in said hydrophobic liquid to produce microcapsules having a diameter of a micellar order of magnitude of 20-200 nanometers; and (d) isolating the resulting microcapsules from the hydrophobic liquid. - View Dependent Claims (4, 5, 6, 7)
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Specification