Bandage for transdermally administering scopolamine to prevent nausea
First Claim
1. A therapeutic system in the form of a bandage for administering scopolamine base through unbroken skin to inhibit emesis and nausea for a prolonged time period comprising a sandwich-type laminate of:
- (a) a backing lamina that is substantially impermeable to scopolamine base, one face of which forms the top of the bandage;
(b) a scopolamine base reservoir lamina adjacent the opposite face of the backing lamina comprisingi. (c) 0.2 to about 3 mg scopolamine base dispersed in a gelled mixture of(ii) mineral oil of about 10 to about 100 cp at 25°
C., and polyisobutene;
(c) a microporous membrane lamina adjacent and below the scopolamine reservoir lamina through which the scopolamine base is released from the reservoir lamina after the bandage is affixed to the skin at a substantially constant rate in the range of about 0.3 to about 15 μ
g/hr; and
(d) a contact adhesive lamina adjacent and below the microporous membrane lamina by which said bandage is affixed to the skin comprising about 10 to about 200 μ
g scopolamine base per cm2 effective surface area dispersed in a gelled mixture of said mineral oil and said polyisobutene.
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Accused Products
Abstract
Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 μg/cm2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 μg/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.
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Citations
12 Claims
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1. A therapeutic system in the form of a bandage for administering scopolamine base through unbroken skin to inhibit emesis and nausea for a prolonged time period comprising a sandwich-type laminate of:
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(a) a backing lamina that is substantially impermeable to scopolamine base, one face of which forms the top of the bandage; (b) a scopolamine base reservoir lamina adjacent the opposite face of the backing lamina comprising i. (c) 0.2 to about 3 mg scopolamine base dispersed in a gelled mixture of (ii) mineral oil of about 10 to about 100 cp at 25°
C., and polyisobutene;(c) a microporous membrane lamina adjacent and below the scopolamine reservoir lamina through which the scopolamine base is released from the reservoir lamina after the bandage is affixed to the skin at a substantially constant rate in the range of about 0.3 to about 15 μ
g/hr; and(d) a contact adhesive lamina adjacent and below the microporous membrane lamina by which said bandage is affixed to the skin comprising about 10 to about 200 μ
g scopolamine base per cm2 effective surface area dispersed in a gelled mixture of said mineral oil and said polyisobutene. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification