Transcutaneous pH measuring instrument

• US 4,033,330 A
• Filed: 09/08/1975
• Issued: 07/05/1977
• Est. Priority Date: 09/08/1975
• Status: Expired due to Term

• Current Assignee: Hewlett-Packard Company (HP Inc.)
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Willis, Barry G., Farrell, Michael J., Schade, Henry A. Jr.
• Primary Examiner(s): Howell, Kyle L.
• Application Number:
  US05/611,387
• Time in Patent Office: 666 Days
• Field of Search: 128/2 L, 128/2 E, 128/2 G, 128/2 A, 128/2.1 E, 356/39, 356/42
• US Class Current: 600/366
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1491 Heated applicators

Abstract

A transcutaneous pH measuring device is provided in which a known volume of fluid is brought into equilibrium with body fluids through a membrane on a portion of skin whose surface layers have been stripped away. The fluid contains a pH sensitive dye. Optical measurements of the transmission characteristics of the fluid are obtained when the fluid is in the optical path. During portions of each operating cycle, the fluid is driven back into the vicinity of the skin to pH equilibrate with body fluids while standardization measurements are obtained using an optical plug of known transmission characteristics in the optical path.

Claims

1. A device for measuring the concentration of a substance in the blood, said device comprising:

a housing;

optical radiation source means mounted within said housing for providing optical radiation having at least one predetermined frequency component;

detector means mounted within said housing for detecting radiation at said at least one predetermined frequency;

a measuring chamber positioned within said housing in an optical path between said source means and said detector means;

means in the housing for maintaining a volumetric region adjacent an area of skin surface of the body when the device is brought into intimate contact with said area, said means allowing said substance in the blood to pass freely between the skin surface and said volumetric region while preventing the passage of undesired substances therebetween;

a measuring fluid in said volumetric region, said fluid having radiation absorption characteristics as a function of wavelength which vary as a function of the concentration of said substance in the blood; and

means for drawing measuring fluid from said volumetric region into said measuring chamber and forcing measuring fluid from said measuring chamber into the volumetric region.

2. A device as in claim 1 further comprising:

standard means movably mounted in said housing for insertion into said measuring chamber when said measuring fluid is forced into said volumetric region, whereby said detector means is enabled to detect radiation passing through said standard means.

3. A device as in claim 2 wherein:

said measuring fluid comprises a plurality of components, each component having a radiation transmission spectrum including a transmission minimum at a separate wavelength; and

said detector means is adapted for detecting radiation at each of said separate wavelengths and at another common wavelength at which each of said components has a transmission maximum.

4. A device as in claim 3 wherein said measuring fluid comprises a solution of phenol red dye.

5. A device as in claim 2 wherein said measuring fluid comprises a solution of phenol red dye.

6. A device as in claim 1 wherein:

said measuring fluid comprises a plurality of components, each component having a radiation transmission spectrum including a transmission minimum at a separate wavelength; and

said dectector means is adapted for detecting radiation at each of said separate wavelengths and at another common wavelength at which each of said components has a transmission maximum.

7. A device as in claim 1 further comprising:

temperature sensing and control means for regulating temperatures in the vicinity of said housing.