Osmotic therapeutic system for administering medicament
First Claim
1. An osmotic therapeutic system for the continuous administration of a medicament to an environment of use, said system comprising:
- a. a wall formed of a material that maintains its integrity during the administration of medicament, is permeable to the passage of an external fluid present in the environment of use and is substantially impermeable to the passage of medicament, with the wall at least partially surrounding a reservoir;
b. a reservoir formed of a material that provides a supporting structure for a multiplicity of microscopic sized interconnected pores;
c. a medicament in the reservoir that can be administered from the system to produce a beneficial result;
d. a passageway for administering the medicament from the system, said passageway communicating with the reservoir and the interior of the system; and
e. wherein in operation with the system in the environment of use, external fluid is continuously imbibed through the wall into the reservoir in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously forming a solution containing medicament which is administered from the system through the passageway to the exterior of the system at a controlled rate over a prolonged period of time to produce the beneficial result.
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Abstract
An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding in at least a part, a reservoir containing agent. The wall is formed of a material permeable to an external fluid and impermeable to agent. The reservoir is formed of a microporous material permeable to agent and fluid, and having at least one micropore that is a passageway for release of agent. The agent is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid, or the agent has limited solubility in the fluid and is admixed with an osmotically effective compound soluble in fluid that exhibits an osmotic pressure gradient against fluid. In operation, agent is released by fluid permeating through the wall into the reservoir producing a solution of agent or a solution of compound containing agent, which solution in either instance is released through the micropore to the exterior of the device.
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Citations
20 Claims
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1. An osmotic therapeutic system for the continuous administration of a medicament to an environment of use, said system comprising:
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a. a wall formed of a material that maintains its integrity during the administration of medicament, is permeable to the passage of an external fluid present in the environment of use and is substantially impermeable to the passage of medicament, with the wall at least partially surrounding a reservoir; b. a reservoir formed of a material that provides a supporting structure for a multiplicity of microscopic sized interconnected pores; c. a medicament in the reservoir that can be administered from the system to produce a beneficial result; d. a passageway for administering the medicament from the system, said passageway communicating with the reservoir and the interior of the system; and e. wherein in operation with the system in the environment of use, external fluid is continuously imbibed through the wall into the reservoir in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously forming a solution containing medicament which is administered from the system through the passageway to the exterior of the system at a controlled rate over a prolonged period of time to produce the beneficial result. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification
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- Resources
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Current AssigneeALZA Corporation (Johnson & Johnson)
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Original AssigneeALZA Corporation (Johnson & Johnson)
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InventorsTheeuwes, Felix
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Primary Examiner(s)Medbery, Aldrich F.
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Application NumberUS05/683,275Time in Patent Office433 DaysField of Search128/260, 128/130, 128/269, 128/272, 128/271, 222/389, 222/491, 424/15, 424/16, 424/37, 3/1US Class Current424/427CPC Class CodesA61F 6/144 with T-configurationA61F 9/0017 implantable in, or in conta...A61K 9/0004 Osmotic delivery systems; S...
