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Osmotic therapeutic system for administering medicament

  • US 4,034,758 A
  • Filed: 05/05/1976
  • Issued: 07/12/1977
  • Est. Priority Date: 09/08/1975
  • Status: Expired due to Term
First Claim
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1. An osmotic therapeutic system for the continuous administration of a medicament to an environment of use, said system comprising:

  • a. a wall formed of a material that maintains its integrity during the administration of medicament, is permeable to the passage of an external fluid present in the environment of use and is substantially impermeable to the passage of medicament, with the wall at least partially surrounding a reservoir;

    b. a reservoir formed of a material that provides a supporting structure for a multiplicity of microscopic sized interconnected pores;

    c. a medicament in the reservoir that can be administered from the system to produce a beneficial result;

    d. a passageway for administering the medicament from the system, said passageway communicating with the reservoir and the interior of the system; and

    e. wherein in operation with the system in the environment of use, external fluid is continuously imbibed through the wall into the reservoir in a tendency towards osmotic equilibrium at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, thereby continuously forming a solution containing medicament which is administered from the system through the passageway to the exterior of the system at a controlled rate over a prolonged period of time to produce the beneficial result.

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