Device for exchange between fluids suitable for treatment of blood

• US 4,038,192 A
• Filed: 07/14/1975
• Issued: 07/26/1977
• Est. Priority Date: 12/03/1973
• Status: Expired due to Term

• Current Assignee: International Biomedical Laboratories Incorporated
• Original Assignee: International Biomedical Laboratories Incorporated
• Inventors: Serur, Juan Ricardo
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/595,846
• Time in Patent Office: 743 Days
• Field of Search: 210/22, 210/321, 210/494, 23/258.5 M
• US Class Current: 210/321.72
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 63/0822 Plate-and-frame devices

Abstract

A device for exchange between fluids, shown especially adapted for exchange between blood and a treatment fluid. The device comprises a first set of fluid channels for blood and a second set of channels for a treatment fluid. Each channel of the first set is defined by a pair of panels of semi-permeable membrane which are supported along spaced-apart lines by supports. At least a portion of the channels of the second set are defined by a pair of membrane panels and a pair of the supports. Each set of channels is arranged into a plurality of layers, the layers alternating between channels of the first and second sets. The resulting three dimensional array of blood and treatment fluid paths enables strict channeling to ensure equal exposure and flow of all blood and treatment fluid while simultaneously achieving double exposure of the treatment fluid as it flows between layers of blood.

Claims

1. In a device for treating blood comprising blood flow paths defined by semi-permeable membrane walls and treatment fluid paths exposing the blood to the treatment fluid across said membrane walls, the improvement wherein the blood flow paths comprise a three dimensional array of narrow, elongated adjacent channels each defined by a pair of opposed membrane panels supported at channel edges by linear support structure, and said treatment fluid paths extend through the array having opposite sides along their length defined by and exposed to panels of different blood channels of said array.

2. The device according to claim 1 wherein said treatment fluid paths include at least one layer of narrow, elongated channels extending parallel to said blood channels, said layer disposed between and exposed on both sides to layers of said blood channels, the blood and treatment fluid channels mutually constructed to produce substantially uniform flow conditions for all blood and for all treatment fluid.

3. The device according to claim 2 wherein a three-dimensional array of parallel, elongated, aligned support members cooperate to define said blood channels and treatment fluid channels, pairs of edge-opposed support members engaging respective pairs of membrane panels to define the edges of respective blood channels, and pairs of side-opposed support members cooperating with panels of side-opposed blood channels to define respective treatment fluid channels.

4. The device according to claim 3 in the form of a stack of subunits, each subunit comprising a plurality of said support members joined by a frame, adjacent subunits in said stack separated by two thicknesses of said membrane.

5. The device according to claim 4 wherein adjacent pairs of said subunits include aligned recesses extending cross-wise to said support members, defining means for delivering untreated blood to a first end of each blood channel.

6. The device according to claim 4 wherein a passage extends through each subunit cross-wise to said support members, defining means for delivering treatment fluid to the treatment fluid channels defined between said support members.

7. The device according to claim 2 wherein there are a plurality of layers of treatment fluid channels and a treatment fluid inlet arrangement is provided to cause treatment fluid to flow in series through flow paths in successive layers whereby each element of treatment fluid is employed to treat blood in numerous blood channels.

8. The device according to claim 1 wherein a blood inlet arrangement is provided to divide a supply of blood into parallel discrete smaller streams through respective blood channels whereby uniform flow conditions and treatment can be assured for the blood.

9. In a device for providing exchange between a first and second fluid comprising first fluid flow paths defined by semi-permeable membrane walls and second fluid paths exposed to the first fluid across said membrane walls, the improvement wherein the first fluid flow paths comprise a three dimensional array of narrow, elongated adjacent channels each defined by a pair of opposed membrane panels supported at channel edges by linear support structure, said second fluid paths extending through the array having opposite sides along their length exposed to panels of different first fluid channels of said array, said second fluid paths including at least one layer of narrow, elongated channels extending parallel to said first fluid channels, said layer disposed between and exposed on both sides to layers of said first fluid channels.

10. In a device for providing exchange between a first and second fluid comprising first fluid flow paths defined by semi-permeable membrane walls and second fluid paths exposed to the first fluid across said membrane walls, the improvement wherein the first fluid flow paths comprise a three dimensional array of narrow, elongated adjacent channels each defined by a pair of opposed membrane panels supported at channel edges by linear support structure, said second fluid paths extending through the array having opposite sides along their length exposed to panels of different first fluid channels of said array, said second fluid paths including at least one layer of narrow, elongated channels extending parallel to said first fluid channels, said layer disposed between and exposed on both sides to layers of said first fluid channels and wherein a three-dimensional array of parallel, elongated, aligned support members cooperate to define said first fluid and second fluid channels, pairs of edge-opposed support members engaging respective pairs of membrane panels to define the edges of respective first fluid channels, and pairs of side-opposed support members cooperating with panels of side-opposed first fluid channels to define respective second fluid channels.

11. The device of claim 10 wherein said support members defining said layer of second fluid channels comprise elongated ribs having oppositely directed parallel edge surfaces engaging membrane panels of layers of first fluid channels, walls of said ribs between the respective edges preventing communication between adjacent second fluid channels and effectively constraining second fluid in said layer to flow uniformly between and be exposed to opposed layers of said first fluid.

12. The device of claim 11 wherein said ribs terminate at each end at cross members, said cross members including internal passages communicating with the second fluid channels between said ribs, and cross members of successive sets of said ribs cooperating to define passages communicating with first fluid channels.